DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCTD16

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001357415.1	Gene:	KCTD16 / 57528	HGNCID:	29244	Length:	428	Species:	Homo sapiens

Alignment Length:	324	Identity:	62/324 - (19%)
Similarity:	105/324 - (32%)	Gaps:	145/324 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDP---ILNE--------YFFDRHPGVFAQV 80
            |.|||||..:.|..:||..||.:.|.::      :.|   ..|:        :|.||...:|..:
Human    27 VELNVGGQVYFTRHSTLISIPHSLLWKM------FSPKRDTANDLAKDSKGRFFIDRDGFLFRYI 85

  Fly    81 LNYYRTGKL----HYPTDVCGPLFEEELEFWGL---------DSNQVEP---CCWMTYTQHRDTQ 129
            |:|.|..::    |:|..  |.| :.|.|::.|         |..:..|   |       |.|.:
Human    86 LDYLRDRQVVLPDHFPEK--GRL-KREAEYFQLPDLVKLLTPDEIKQSPDEFC-------HSDFE 140

  Fly   130 ETLAVLDRLDLDTEKPSEEELA---------RKFGFEEDYYKGTISWWQEMK--------PRIWS 177
                       |..:.|:..:.         ||:||....|:|:.:..:|.:        |||
Human   141 -----------DASQGSDTRICPPSSLLPADRKWGFITVGYRGSCTLGREGQADAKFRRVPRI-- 192

  Fly   178 LFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQT-N 241
                                .:|             .|:.:.:.:..:|.|.|.    |..:. .
Human   193 --------------------LVC-------------GRISLAKEVFGETLNESR----DPDRAPE 220

  Fly   242 AHIAFFYI-------------EC-----VCNA---------------WFTFEILVRFISSPNKW 272
            .:.:.||:             ||     .||:               |.::...| |...|::|
Human   221 RYTSRFYLKFKHLERAFDMLSECGFHMVACNSSVTASFINQYTDDKIWSSYTEYV-FYREPSRW 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	31/124 (25%)
		BTB_2	27..117	CDD:280393	30/116 (26%)
		Ion_trans	244..439	CDD:278921	11/62 (18%)
		Ion_trans_2	355..429	CDD:285168
KCTD16	NP_001357415.1	BTB_POZ_KCTD16	23..125	CDD:349706	28/106 (26%)
KCTD16	NP_001357415.1	H1_KCTD16	160..280	CDD:409030	25/159 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910