DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and kcnd2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001076336.1	Gene:	kcnd2 / 570188	ZFINID:	ZDB-GENE-041210-70	Length:	630	Species:	Danio rerio

Alignment Length:	632	Identity:	185/632 - (29%)
Similarity:	290/632 - (45%)	Gaps:	157/632 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHY 91
            ::|||.|.|.:|::.||::.|.|.|.. ||....:....|||||||.|.:|..:||:||||||||
Zfish    42 IILNVSGTRFQTWRNTLERYPDTLLGS-TERDFFFHEETNEYFFDRDPDIFRHILNFYRTGKLHY 105

  Fly    92 PTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELAR-KFG 155
            |...|...::|||.|:|:....:..||   |.:::|.:...|  :|:..|.|..:..:|.. ...
Zfish   106 PRHECISAYDEELAFFGIIPEIIGDCC---YEEYKDRRRENA--ERIQDDEENDNNNDLVMPDLS 165

  Fly   156 FEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVR 220
            |.|.               :|..|:.|::|..|.....|:.|||.:|:::..::|.|   ..|..
Zfish   166 FRES---------------MWRAFENPHTSTMALVFYYVTGFFIAVSVMANVVETVP---CGISL 212

  Fly   221 NITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYI 285
            |...:.:.|.          ...:|||.::..|...||.|.|:|.|::|::::|:||.::|||.:
Zfish   213 NRAKELSCGE----------RYALAFFCLDTACVMIFTVEYLLRLIAAPSRYKFVKSVMSIIDVV 267

  Fly   286 ATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLL 347
            |.:.:||.||:      .:|.|:...|   .:.|:.|:||.:|||:||:||..|.::.|.||..|
Zfish   268 AIMPYYIGLVM------TDNEDVSGAFVTLRVFRVFRIFKFSRHSAGLRILGYTLKSCASELGFL 326

  Fly   348 VFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALC 412
            :|.|.:.|:|||::::|||:  .:..:.|.|||...|:.:|||||:|||||.|||.:|...|::|
Zfish   327 LFSLTMAIIIFATVMFYAEK--GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIMGKIFGSIC 389

  Fly   413 ALAGVLTIALPVPVIVSNFAMYYSHTQ-----------------------ARAKLPKKRRRVL-- 452
            :|:|||.||||||||||||:..|..:|                       |.|.|..||..:|
Zfish   390 SLSGVLVIALPVPVIVSNFSRIYHQSQRAEKRRAQKKTRLARIRAAKSGGANAYLQYKRNGMLVD 454

  Fly   453 -----------------------------------------------------PVEQP---RQPR 461
                                                                 .:.:|   |...
Zfish   455 MEEEASKEAGQALVCKANPTFETQHHHLLHCLEKTTNHEFVDEQTYETSCMEVSLAKPSMSRSSS 519

  Fly   462 LPGAPGGVSGCGT----------PGSGPHSGPMGSGGTGPRRMNNKTKDLVSPKSVAQLFAGPLG 516
            :..:|.|:|.|.|          |.|....|..||               :...|..|:...||.
Zfish   520 MSSSPHGLSSCCTRRNKRKSFNVPNSNMAGGRRGS---------------IQELSTIQIRERPLS 569

  Fly   517 ASIVAMSPRTMLDLNPALAMGKPTFQPRIPTPLAATPPPPVSSAGGM 563
            .|..:::.:  .:....|...:|::   |...:.:.|.|||::..|:
Zfish   570 NSRSSLNAK--FEETVPLNSEEPSY---ITAAVISMPTPPVTTPEGV 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	42/97 (43%)
		BTB_2	27..117	CDD:280393	39/89 (44%)
		Ion_trans	244..439	CDD:278921	88/197 (45%)
		Ion_trans_2	355..429	CDD:285168	40/73 (55%)
kcnd2	NP_001076336.1	Shal-type	3..28	CDD:288455
		BTB	42..139	CDD:197585	42/100 (42%)
		BTB_2	42..131	CDD:280393	39/89 (44%)
		Ion_trans	228..416	CDD:278921	87/195 (45%)
		Ion_trans_2	330..410	CDD:285168	45/81 (56%)
		DUF3399	444..548	CDD:288712	13/103 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810