DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnv2b

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001122212.1	Gene:	kcnv2b / 567780	ZFINID:	ZDB-GENE-060526-28	Length:	527	Species:	Danio rerio

Alignment Length:	463	Identity:	139/463 - (30%)
Similarity:	220/463 - (47%)	Gaps:	78/463 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LNVGGIRHETYKATLK---KIPATRLSRLT---------EALANYDPILNEYFFDRHPGVFAQVL 81
            |||||   ::|:.|.|   :.|.|||.||.         :...:|....|||||||.|.||..:.
Zfish    84 LNVGG---KSYRITYKMAARYPQTRLGRLAMSTDLNMKMDLCDDYVVKDNEYFFDRDPDVFNSIF 145

  Fly    82 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQ-ETLAVLDRLDLDTEKP 145
            |:||||.|....::|...|.||:.:||:.....:.||.:...:..|.. |.|.|...|:.:.|..
Zfish   146 NFYRTGVLWIKDELCPRNFLEEISYWGVRIKYSQRCCRILLEEKNDELCEQLKVQKELERELEIE 210

  Fly   146 SEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKT 210
            ..||..      :|...|      |.:..:|...::|:||..||.:.|.|..|:.||:::..|.|
Zfish   211 ENEEAF------DDMILG------ESRRSLWDFMEKPFSSIPAKLMAVTSSMFVLISLVTMTLST 263

  Fly   211 HPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFI 275
            ..:|     .||..:..|...                ::|.:|..:||.|.|:|.||:|:...|.
Zfish   264 VEEM-----ENIESEGKNYGE----------------FVENLCITFFTIEYLLRVISTPDICRFF 307

  Fly   276 KSSVNIIDYIATLSFYIDLVLQR---FASHLENAD------------ILEFFSIIRIMRLFKLTR 325
            ||.:|.:|.:|.|...:..:|:.   |.|..::||            :|....::||.|:.||.|
Zfish   308 KSMLNAVDLMAILPQILQFMLENFETFGSRNQSADMETVGQVGKVGQVLRIMRLLRIFRVLKLAR 372

  Fly   326 HSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTM 390
            ||:||:....|.:...:::..|..|:.:||..|:::||..|  ...|..:|.|||...|||.|::
Zfish   373 HSTGLRAFGFTLKQCYQQVGCLFLFIAMGIFTFSAMVYSVE--YDVPKTNFTSIPHSWWWASVSI 435

  Fly   391 TTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY---------SHTQARAK--- 443
            :|||||||.|:|.:|......|...|::...||:.::.:.|:.||         ||.:.|..
Zfish   436 STVGYGDMYPETLLGRIFAFGCISFGIILNGLPISILFNKFSDYYAKLKSHECPSHMKNRGNVNF 500

  Fly   444 LPKKRRRV 451
            :|:.::::
Zfish   501 IPRAKKKL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	39/107 (36%)
		BTB_2	27..117	CDD:280393	37/99 (37%)
		Ion_trans	244..439	CDD:278921	70/218 (32%)
		Ion_trans_2	355..429	CDD:285168	28/73 (38%)
kcnv2b	NP_001122212.1	BTB	82..173	CDD:295341	36/91 (40%)
		BTB	84..187	CDD:197585	39/105 (37%)
		Ion_trans	279..484	CDD:278921	68/222 (31%)
		Ion_trans_2	409..478	CDD:285168	27/70 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820