DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnb2b

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_695259.4	Gene:	kcnb2b / 566883	ZFINID:	ZDB-GENE-091113-38	Length:	831	Species:	Danio rerio

Alignment Length:	443	Identity:	173/443 - (39%)
Similarity:	254/443 - (57%)	Gaps:	60/443 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPIL----------NEYFFDRHPGVFAQV 80
            ||.:||||:.||....||.::|.|||.:|.:. ..:|.::          ||||||||||.|..:
Zfish    36 RVRINVGGLNHEVLWRTLDRLPRTRLGKLRDC-NTHDSLMEVCDDYCLNENEYFFDRHPGAFTSI 99

  Fly    81 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKP 145
            ||:|||||||...::|...|.:||::||:|...:|.||...|.|.::           .::.|..
Zfish   100 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKE-----------QMNEELR 153

  Fly   146 SEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKT 210
            .|.|..|:...|.::..   :...|.:.::|.|.::|.||.|||.:.::|:.||.:|.::..|.|
Zfish   154 REAETLREREGEGEFDN---TCCPEKRKKLWELLEKPSSSVAAKILAIISILFIVLSTVALSLNT 215

  Fly   211 HPDMRVPIVRNITVKTANGSNGWFLDK-TQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEF 274
            .|:::|                  .|: .|.|.:....::|.||.||||.|.|:||:||||||:|
Zfish   216 LPELQV------------------TDEFGQANDNPQLAHVEAVCIAWFTMEYLLRFLSSPNKWKF 262

  Fly   275 IKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEF---------FSIIRIMRLFKLTRHSSGL 330
            .|..:|:||.:|.|.:|:.:.|..     .|..:|:|         |.|:||:|:.||.|||:||
Zfish   263 FKGPLNVIDLLAILPYYVTIFLTE-----SNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGL 322

  Fly   331 KILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGY 395
            :.|..|.|.|..||.||:.||.:||:||:|||::||:  ......|.|||...|||.:|||||||
Zfish   323 QSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDATKFTSIPASFWWATITMTTVGY 385

  Fly   396 GDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKR 448
            ||:.|:|.:|..||.||.:||||.||||:|:||:||:.:|...:.:.|..|:|
Zfish   386 GDIYPQTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRR 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	46/107 (43%)
		BTB_2	27..117	CDD:280393	43/99 (43%)
		Ion_trans	244..439	CDD:278921	97/203 (48%)
		Ion_trans_2	355..429	CDD:285168	41/73 (56%)
kcnb2b	XP_695259.4	BTB	37..143	CDD:197585	46/106 (43%)
		BTB_2	37..136	CDD:280393	43/99 (43%)
		Ion_trans	231..429	CDD:278921	97/204 (48%)
		Ion_trans_2	342..423	CDD:285168	47/82 (57%)
		Kv2channel	480..706	CDD:281514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810