DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and kcng4b

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_009301775.1	Gene:	kcng4b / 566228	ZFINID:	ZDB-GENE-130530-634	Length:	535	Species:	Danio rerio

Alignment Length:	474	Identity:	139/474 - (29%)
Similarity:	219/474 - (46%)	Gaps:	83/474 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LINMDSENRVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRH 73
            |.::|.....::||||.|:....:||.:.|.:||.:|         .:...:||....|:||||.
Zfish    53 LKDVDHSKLALINVGGDRYTFPWSTLDEFPLSRLGQLRHCSSPDDIAQLCDDYDEARREFFFDRS 117

  Fly    74 PGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL 138
            ...|..:||:...|||.....||.....:||.:||:|...:|.||            ...:|.|:
Zfish   118 SVAFRVILNFLAAGKLRLLRQVCAVSLSDELTYWGIDPVHMERCC------------RRKLLSRV 170

  Fly   139 DLDTEKPSEEE------------LARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTI 191
            :...||..:|:            ||:..||            ..:..|:..:.:.|:|..|.|..
Zfish   171 EDVAEKKKKEDERKQKRHALQRPLAQDKGF------------IRLMNRLQEIVENPHSGWAGKLF 223

  Fly   192 GVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAW 256
            ...||..|.::::|.|:.|.||              :.:.|...:|.:.     .|.:|.||.||
Zfish   224 ACFSVVMIAVTVISLCISTLPD--------------HENRGECTEKCRN-----IFIVETVCVAW 269

  Fly   257 FTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQ----RFASHLENAD---------- 307
            |:.|.|:||:.:.:|.:|:::.:|:||.||.|.:||.||:.    ...:.|..|.
Zfish   270 FSMEFLLRFLQAESKMQFLRNPLNVIDVIAILPYYISLVVDSEDTSDEAELNGAGTSRGYLDKLG 334

  Fly   308 -ILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERI--- 368
             ||.....:||:.:.:|.|||.||:.|..|.:.|.:|..||:.||.:.:.:|:.||:.||:.
Zfish   335 LILRVMRALRILYVMRLARHSLGLQTLGLTMQRSMREFGLLLLFLCVAVALFSPLVHLAEKEFSK 399

  Fly   369 -QPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFA 432
             :....|.|:|||...|||:::|||||||||.|.:..|..|.....|:|:|.:|.|...|...|:
Zfish   400 GKATGPNSFSSIPASYWWAIISMTTVGYGDMVPYSIPGQVVAFSSILSGILIMAFPATSIFHVFS 464

  Fly   433 MYYSHTQARAKLPKKRRRV 451
            ..|...:...::..|..||
Zfish   465 RSYHELKREQEMIYKEERV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	34/106 (32%)
		BTB_2	27..117	CDD:280393	32/98 (33%)
		Ion_trans	244..439	CDD:278921	76/213 (36%)
		Ion_trans_2	355..429	CDD:285168	31/77 (40%)
kcng4b	XP_009301775.1	BTB_2	64..161	CDD:280393	32/96 (33%)
		BTB	<102..163	CDD:197585	23/72 (32%)
		Ion_trans	259..471	CDD:278921	76/211 (36%)
		Ion_trans_2	<414..465	CDD:285168	22/50 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810