DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and Kcnd3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_064315.1	Gene:	Kcnd3 / 56543	MGIID:	1928743	Length:	655	Species:	Mus musculus

Alignment Length:	652	Identity:	199/652 - (30%)
Similarity:	314/652 - (48%)	Gaps:	111/652 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AHAAMNLINMDSENR----VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDR 72
            |:..|.|...|...|    :||||.|.|.:|::.||::.|.|.|.. ||....::....||||||
Mouse    23 ANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEDTKEYFFDR 86

  Fly    73 HPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDR 137
            .|.||..|||:|||||||||...|...:::||.|:|:....:..||   |.:::|.:...|  :|
Mouse    87 DPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCC---YEEYKDRKRENA--ER 146

  Fly   138 LDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICIS 202
            |..|.:..:.:|......|.:               .:|..|:.|::|..|.....|:.|||.:|
Mouse   147 LMDDNDSENNQESMPSLSFRQ---------------TMWRAFENPHTSTLALVFYYVTGFFIAVS 196

  Fly   203 ILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFIS 267
            :::..::|.|...||           ||......:..:   :|||.::..|...||.|.|:|..:
Mouse   197 VITNVVETVPCGTVP-----------GSKELPCGERYS---VAFFCLDTACVMIFTVEYLLRLFA 247

  Fly   268 SPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSG 329
            :|:::.||:|.::|||.:|.:.:||.||:      ..|.|:...|   .:.|:.|:||.:|||.|
Mouse   248 APSRYRFIRSVMSIIDVVAIMPYYIGLVM------TNNEDVSGAFVTLRVFRVFRIFKFSRHSQG 306

  Fly   330 LKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVG 394
            |:||..|.::.|.||..|:|.|.:.|:|||::::|||:  .:..:.|.|||...|:.:|||||:|
Mouse   307 LRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPASFWYTIVTMTTLG 369

  Fly   395 YGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFA-MYYSHTQARAKLPKKRRRVLPVEQPR 458
            ||||.|||..|...|::|:|:|||.||||||||||||: :|:.:.:|..:..:|:.|:..:.
Mouse   370 YGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIR--- 431

  Fly   459 QPRLPGAPGGVSGCGTPGSGPHSGPMG-------SGGTGPRRMNNKTKDLVSPK----------- 505
                      |:..|:..:..||...|       ..||.......||..|:..:
Mouse   432 ----------VAKTGSSNAYLHSKRNGLLNEALELTGTPEEEQMGKTTSLIESQHHHLLHCLEKT 486

  Fly   506 -SVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKPTFQPRIPTPL---AATPPPPVSSAGGMTAS 566
             .::.|...||      :|.||....|......:...|..:.:.:   .:|..|.:||..|:|.:
Mouse   487 TGLSYLVDDPL------LSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTT 545

  Fly   567 GIGTTS--ATGATSAPQPATPL----------------PSIAVS-TTASVGKDLGISTTTTTAQE 612
            .....|  .|...::..|||.|                ||:..| ::.::..|.|:.....|:|.
Mouse   546 CCSRRSKKTTHLPNSNLPATRLRSMQELSTLHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQI 610

  Fly   613 TS 614
            |:
Mouse   611 TT 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	43/97 (44%)
		BTB_2	27..117	CDD:280393	40/89 (45%)
		Ion_trans	244..439	CDD:278921	87/198 (44%)
		Ion_trans_2	355..429	CDD:285168	40/73 (55%)
Kcnd3	NP_064315.1	Interaction with KCNIP2. /evidence=ECO:0000250	2..20
		BTB_POZ_KCND3	6..143	CDD:349726	49/123 (40%)
		Ion_trans	182..412	CDD:366146	99/251 (39%)
		Selectivity filter. /evidence=ECO:0000250	367..372		3/4 (75%)
		DUF3399	442..563	CDD:371777	24/126 (19%)
		Mediates dendritic targeting. /evidence=ECO:0000250	472..487		0/14 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..565		9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	615..655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810