DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnc3b

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_021325878.1	Gene:	kcnc3b / 564371	ZFINID:	ZDB-GENE-100901-2	Length:	658	Species:	Danio rerio

Alignment Length:	518	Identity:	243/518 - (46%)
Similarity:	319/518 - (61%)	Gaps:	81/518 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTE--ALAN--YDPILNEYFFDRHPGVFAQVLN 82
            :|| ::|:|.||:|||||::|||.:|.||||.|||  |.:|  |||..:|:||||||.||:.:||
Zfish    34 ESE-KIVINCGGVRHETYRSTLKTLPGTRLSWLTEPDAFSNFDYDPKSDEFFFDRHPSVFSFILN 97

  Fly    83 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDL-DTEKPS 146
            ||||||||.|.|||||||||||.|||:|...||.||||.|.||||.:|   .||..:. :.|.|.
Zfish    98 YYRTGKLHCPNDVCGPLFEEELAFWGIDETDVEACCWMNYRQHRDAEE---ALDSFETPEPEVPD 159

  Fly   147 EE-ELA-----RKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILS 205
            :: .||     ::...:||..|.  .||:..:||||:||::||||..|:.:...|:.||.|||.:
Zfish   160 DDPALAGDGDLKRLCLQEDGRKA--GWWRVWRPRIWALFEDPYSSKYARYVAFGSLLFILISIST 222

  Fly   206 FCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAF--------FYIECVCNAWFTFEIL 262
            ||::||     .....|..||.|.:.|     ..|...|.:        .|:|.||..|||.|:.
Zfish   223 FCMETH-----EAFNTIYNKTENVTEG-----NVTREEIVYEVVTDSWLTYVEGVCVVWFTIEVF 277

  Fly   263 VRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSI---IRIMRLFKLT 324
            .|.:..|:|.||.||.:||||::|.|.||:::.|...:|.... |:|.|..:   :||:|:||||
Zfish   278 TRVVFCPDKMEFFKSPLNIIDFVAVLPFYLEVGLSGLSSKAAK-DVLGFLRVVRFVRILRIFKLT 341

  Fly   325 RHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNP-------HNDFNSIPLG 382
            ||..||::|..|.|||..|..||:.||.||::|||:::||||||..:|       |.:|.:||:|
Zfish   342 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGASPDDPTASAHTNFKNIPIG 406

  Fly   383 LWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKK 447
            .|||:|||||:|||||.|:|:.||.||||||||||||||:||||||:||.||||...|:.|||||
Zfish   407 FWWAVVTMTTLGYGDMYPETWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK 471

  Fly   448 RRRVLPVEQPRQPRLPGAP-------------------GGVSGCGTPGSGPHSGPMGSGG-TG 490
            :.:.:    ||.|: ||:|                   |.|.|          |.:||.| ||
Zfish   472 KNKHI----PRAPQ-PGSPNYCKPDALAMATASPQRILGNVLG----------GVLGSSGLTG 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	67/101 (66%)
		BTB_2	27..117	CDD:280393	62/93 (67%)
		Ion_trans	244..439	CDD:278921	110/212 (52%)
		Ion_trans_2	355..429	CDD:285168	51/80 (64%)
kcnc3b	XP_021325878.1	Potassium_chann	1..29	CDD:314363
		BTB_2	38..132	CDD:308049	62/93 (67%)
		Ion_trans	205..463	CDD:306908	127/268 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2066
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1537
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	1	1.000	-	-		otm25615
orthoMCL	1	0.900	-	-		OOG6_102927
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970