DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcna4

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_005169005.1	Gene:	kcna4 / 559036	ZFINID:	ZDB-GENE-121127-2	Length:	667	Species:	Danio rerio

Alignment Length:	531	Identity:	196/531 - (36%)
Similarity:	267/531 - (50%)	Gaps:	132/531 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKL 89
            |||:||.|::.||...||.:.|.|.|....:....:||:.|||||||:...|..:|.:|:: |:|
Zfish   206 RVVINVSGLKFETQLKTLAQFPDTLLGDPEKRSRYFDPLRNEYFFDRNRPSFDAILYFYQSGGRL 270

  Fly    90 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKF 154
            ..|.:|...:|.||::|:.|....:        .:.|:.:..:.       :.|||..|:
Zfish   271 KRPVNVPFDIFSEEVKFYELGDEAM--------LKFREDEGFVK-------EEEKPLPED----- 315

  Fly   155 GFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMR---- 215
                           |.|.:||.||:.|.||:.|:.|.||||..|.|||:.|||:|.|:.|
Zfish   316 ---------------EFKRQIWLLFEYPESSSPARGIAVVSVLVIVISIVIFCLETLPEFRDDKE 365

  Fly   216 --VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSS 278
              :|           |.|....|...|..:..||.:|.||..||:|||:|||.:||:|.:|.|:.
Zfish   366 FLIP-----------GKNSTQADNGFTPFNDPFFIVETVCIIWFSFEIIVRFFASPSKADFFKNV 419

  Fly   279 VNIIDYIATLSFYI----DLVLQR--------FASHLENADILEFFSIIRIMRLFKLTRHSSGLK 331
            :|.||.::.|.::|    ||..|:        ||       ||....::|:.|:|||:|||.||:
Zfish   420 MNTIDIVSILPYFITLGTDLAQQQGNGQQAMSFA-------ILRIIRLVRVFRIFKLSRHSKGLQ 477

  Fly   332 ILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYG 396
            ||..|.|||.:||.||:||||:|:::|:|.||:||..:|.  :.|.|||...|||:|||||||||
Zfish   478 ILGHTLRASMRELALLIFFLVIGVILFSSAVYFAEADEPT--SQFTSIPDAFWWAVVTMTTVGYG 540

  Fly   397 DMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY-----SHTQARAKLPKKRRRVLPVEQ 456
            ||.|.|..|..||:|||:|||||||||||||||||..:|     :..||.|           |||
Zfish   541 DMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDNEDQAPA-----------VEQ 594

  Fly   457 PRQPRLPGAP----------GGVSG---------------------CGTPGSGPHSGPMGSGGT- 489
            |.    ||.|          |..||                     ||    |....|....||
Zfish   595 PP----PGCPYFPDFLRKFKGSPSGSSLGDKAAEYMEMEEGVTESLCG----GDTQSPSRGNGTD 651

  Fly   490 --GPRRMNNKT 498
              |....:::|
Zfish   652 LGGKNSSHSRT 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	33/98 (34%)
		BTB_2	27..117	CDD:280393	33/90 (37%)
		Ion_trans	244..439	CDD:278921	106/211 (50%)
		Ion_trans_2	355..429	CDD:285168	46/73 (63%)
kcna4	XP_005169005.1	K_channel_TID	1..70	CDD:311753
		BTB_2	207..295	CDD:308049	33/87 (38%)
		Ion_trans	382..582	CDD:306908	106/208 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810