DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcns3b

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001032460.1	Gene:	kcns3b / 558674	ZFINID:	ZDB-GENE-051120-78	Length:	424	Species:	Danio rerio

Alignment Length:	447	Identity:	136/447 - (30%)
Similarity:	227/447 - (50%)	Gaps:	59/447 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ENRVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVFAQ 79
            |:.|.||:|||.|:..:..|.:.|.||:::|         .|...:|.|...||:|||.|.||..
Zfish    14 EDLVNLNIGGIHHKVERCVLLRFPHTRVAQLIQCHSDAAILELCDDYSPTEQEYYFDRSPQVFHC 78

  Fly    80 VLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEK 144
            |||:||||..|...::|...|.:|:|:|||....::.||...:.:.:|..|    |:.....::.
Zfish    79 VLNFYRTGHFHTLEELCVFCFSQEIEYWGLCELDLDACCLEWFLERKDEHE----LNSSGQSSKN 139

  Fly   145 PSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLK 209
            .|..|::..   .||.:|.......:::..:|...::|..|..::.:..|||..|.||||:.|:.
Zfish   140 ASSGEISVT---SEDLWKSEGMRCSDVRKLMWETLEDPQHSRCSRGVAAVSVLVILISILAMCVH 201

  Fly   210 THPDMRVPIVRNITVKTANGSNGWFLDKTQTNA-HIAFFYIECVCNAWFTFEILVRFISSPNKWE 273
            :.|:.|.                      ||:. |.....:|..|..:|:.|..:|.|::|....
Zfish   202 SLPEFRY----------------------QTDGEHSVLDSVELFCIVFFSVEFFLRVIAAPQPLR 244

  Fly   274 FIKSSVNIIDYIATLSFYIDLVLQRF--ASHLENADILEFFSIIRIMRL------FKLTRHSSGL 330
            |:.:.:|:||..:.|.|||.|.::|.  ....||..::....:::::||      .||.|||.|:
Zfish   245 FLGNPLNMIDVASILPFYITLAVERLDEEDKEENQSLVNMGRVVQVLRLMRSFRVLKLARHSEGM 309

  Fly   331 KILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGY 395
            :...:|......|:.|||.|:.:||..|::.:||.|:.:.:  :..:|||:..||.:::||||||
Zfish   310 RAFGETLMNCQCEVGLLVLFITVGISFFSTFIYYTEKEEAS--SQLSSIPICWWWGIISMTTVGY 372

  Fly   396 GDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVL 452
            ||:.|.|..|..|..:|.|.|:|.|:||:.:|::||:.|:          :|.|:.|
Zfish   373 GDVYPLTVAGRIVATVCILCGLLVISLPITIIMNNFSKYF----------EKNRKCL 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	40/106 (38%)
		BTB_2	27..117	CDD:280393	38/98 (39%)
		Ion_trans	244..439	CDD:278921	67/202 (33%)
		Ion_trans_2	355..429	CDD:285168	30/73 (41%)
kcns3b	NP_001032460.1	BTB	17..117	CDD:197585	38/99 (38%)
		BTB_2	17..116	CDD:280393	38/98 (39%)
		Ion_trans	205..414	CDD:278921	71/242 (29%)
		Ion_trans_2	329..410	CDD:285168	34/82 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820