DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnq5a

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_021336521.1	Gene:	kcnq5a / 556841	ZFINID:	ZDB-GENE-090312-185	Length:	1030	Species:	Danio rerio

Alignment Length:	291	Identity:	76/291 - (26%)
Similarity:	121/291 - (41%)	Gaps:	57/291 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 KPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSF-CLKTHPDMRVPIVRNITVKTANGSNGWFL 235
            :||.|:.....:         |.::.|.|:.:..| .:..|.|:               ||...|
Zfish   100 RPRAWAFVYHAF---------VFTLVFGCLVLSVFSTIPAHMDL---------------SNHCLL 140

  Fly   236 DKTQTNAHIAFFYIECVCNAWFTFEILVRFISSP-----NKWE----FIKSSVNIIDYIATLSFY 291
                        .:|.|....|..|.::|..|:.     ..|:    |.:....:||.|..:: .
Zfish   141 ------------ILEFVMIVVFGLEYIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDIIVLIA-S 192

  Fly   292 IDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTL--LVFFLVLG 354
            |.:|......::.....|.....::|:|:.::.|.....|:|.....|.:|||..  .:.||||
Zfish   193 IAVVSAGSQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLVL- 256

  Fly   355 IVIFAS-LVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVL 418
              ||:| |||..|:   ..:..|.:....|||..:|:||:||||..|:|:.|..:.|..||.|:.
Zfish   257 --IFSSFLVYLVEK---EFNKQFATYADALWWGTITLTTIGYGDKTPQTWTGRLLSAGFALLGIS 316

  Fly   419 TIALPVPVIVSNFAMYYSHTQARAKLPKKRR 449
            ..|||..::.|.||:.... |.|.|..:|||
Zfish   317 FFALPAGILGSGFALKVQE-QHRQKHFEKRR 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	58/206 (28%)
		Ion_trans_2	355..429	CDD:285168	28/74 (38%)
kcnq5a	XP_021336521.1	Ion_trans	105..337	CDD:306908	67/275 (24%)
		KCNQ_channel	445..706	CDD:308886
		Herpes_BLLF1	<756..>847	CDD:330317
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810