Protein Alignment Shaw and Kcnf1

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_963289.3
• Gene: Kcnf1 / 382571
• MGIID: 2687399
• Length: 493
• Species: Mus musculus
• Alignment Length: 470
• Identity: 155/470 - (32%)
• Similarity: 228/470 - (48%)
• Gaps: 79/470 - (16%)

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALA-----------NYDPILNEYFFDRHPGVFAQV 80
            :|:||||:|...|...|.:.|.|||:.|...||           :|||...|::|||.|..|..|
Mouse    25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCV 89

  Fly    81 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLA-----VLDRLDL 140
            :..|..|::|....:|...|:.|::||.:|...::.||....::.|:..|.:|     :||.|.:
Mouse    90 IEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGV 154

  Fly   141 DTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILS 205
            |..:                     ..|:..:..:|...::|.||..|:.:.|:|...|.:|.:.
Mouse   155 DAAE---------------------GRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVV 198

  Fly   206 FCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPN 270
            .|:.|.|:::|.......|:                 |.....:|..|..|||.|.|:|..||||
Mouse   199 MCMGTIPELQVVDSEGNRVE-----------------HPTLENVETACIGWFTLEYLLRLFSSPN 246

  Fly   271 KWEFIKSSVNIIDYIATLSFYIDLVLQRFAS---HLENA-DILEFFSIIRIMRLFKLTRHSSGLK 331
            |..|..|.:||:|.:|.|.||:.|.|....:   .|.|. ..::...|:||.|:|||.||||||:
Mouse   247 KLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQ 311

  Fly   332 ILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYG 396
            .|....:.|.|||.||:.:|.:||.:|::|.|..|  |.:|...|.|||...|||::||||||||
Mouse   312 TLTYALKRSFKELGLLLMYLAVGIFVFSALGYTME--QSHPETLFKSIPQSFWWAIITMTTVGYG 374

  Fly   397 DMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPR 461
            |:.|||.:|....|:..|.||:.||||:..|::||..||:           ::|||......:..
Mouse   375 DIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYN-----------KQRVLETAAKHELE 428

  Fly   462 L--------PGAPGG 468
            |        .|.|||
Mouse   429 LMELNSSSAEGKPGG 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	39/123 (32%)
		Ion_trans	188..439	CDD:459842	99/254 (39%)
		PRK14959	<418..>585	CDD:184923	17/59 (29%)
Kcnf1	NP_963289.3	BTB_POZ_Kv5_KCNF1	23..138	CDD:349690	37/112 (33%)
		Ion_trans	181..417	CDD:459842	99/265 (37%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..468		4/10 (40%)