Protein Alignment Shaw and KCNS3

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_002243.3
• Gene: KCNS3 / 3790
• HGNCID: 6302
• Length: 491
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 139/428 - (32%)
• Similarity: 223/428 - (52%)
• Gaps: 44/428 - (10%)

  Fly    24 ENRVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVFAQ 79
            |..|.|||||.:....::||.:.|.|||.:|         .|...:|.....||:|||:|.:|..
Human    14 EELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRY 78

  Fly    80 VLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL--DLDT 142
            |||:|.|||||...::|...|.:|:|:||::...::.||...| |.|..:......|:.  |:.|
Human    79 VLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRY-QERKEENHEKDWDQKSHDVST 142

  Fly   143 EKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFC 207
            :...||...    ||::..|.....:.:::.:||...:.|....:||.|.:.|:..:..||::.|
Human   143 DSSFEESSL----FEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMC 203

  Fly   208 LKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKW 272
            :.:..:.:             ..:|...|.......||       |.||||.|:.||..::|.:.
Human   204 VHSMSEFQ-------------NEDGEVDDPVLEGVEIA-------CIAWFTGELAVRLAAAPCQK 248

  Fly   273 EFIKSSVNIIDYIATLSFYIDLVL---QRFASHLEN-ADILEFFSIIRIMRLFKLTRHSSGLKIL 333
            :|.|:.:||||:::.:.||..|.:   :..:..:|| ..:::...::||.|:.||.|||.||:.|
Human   249 KFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSL 313

  Fly   334 IQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPH-NDFNSIPLGLWWALVTMTTVGYGD 397
            ..|.|.|..|:.||:.||.:||.||:.|:|..|:   :.| :...|||:..|||.::||||||||
Human   314 GATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEK---DDHTSSLTSIPICWWWATISMTTVGYGD 375

  Fly   398 MAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            ..|.|..|..:.:.|.:.|:|.:|||:.:|.:.|:.||
Human   376 THPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYY 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	43/119 (36%)
		Ion_trans	188..439	CDD:459842	85/253 (34%)
		PRK14959	<418..>585	CDD:184923	8/18 (44%)
KCNS3	NP_002243.3	BTB_POZ_KCNS3	15..122	CDD:349735	40/107 (37%)
		Ion_trans	184..417	CDD:459842	85/253 (34%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)