DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNS3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001269357.1	Gene:	KCNS3 / 3790	HGNCID:	6302	Length:	491	Species:	Homo sapiens

Alignment Length:	428	Identity:	139/428 - (32%)
Similarity:	223/428 - (52%)	Gaps:	44/428 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ENRVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVFAQ 79
            |..|.|||||.:....::||.:.|.|||.:|         .|...:|.....||:|||:|.:|..
Human    14 EELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRY 78

  Fly    80 VLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL--DLDT 142
            |||:|.|||||...::|...|.:|:|:||::...::.||...| |.|..:......|:.  |:.|
Human    79 VLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRY-QERKEENHEKDWDQKSHDVST 142

  Fly   143 EKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFC 207
            :...||...    ||::..|.....:.:::.:||...:.|....:||.|.:.|:..:..||::.|
Human   143 DSSFEESSL----FEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMC 203

  Fly   208 LKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKW 272
            :.:..:.:             ..:|...|.......||       |.||||.|:.||..::|.:.
Human   204 VHSMSEFQ-------------NEDGEVDDPVLEGVEIA-------CIAWFTGELAVRLAAAPCQK 248

  Fly   273 EFIKSSVNIIDYIATLSFYIDLVL---QRFASHLEN-ADILEFFSIIRIMRLFKLTRHSSGLKIL 333
            :|.|:.:||||:::.:.||..|.:   :..:..:|| ..:::...::||.|:.||.|||.||:.|
Human   249 KFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSL 313

  Fly   334 IQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPH-NDFNSIPLGLWWALVTMTTVGYGD 397
            ..|.|.|..|:.||:.||.:||.||:.|:|..|:   :.| :...|||:..|||.::||||||||
Human   314 GATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEK---DDHTSSLTSIPICWWWATISMTTVGYGD 375

  Fly   398 MAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            ..|.|..|..:.:.|.:.|:|.:|||:.:|.:.|:.||
Human   376 THPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYY 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	40/106 (38%)
		BTB_2	27..117	CDD:280393	37/98 (38%)
		Ion_trans	244..439	CDD:278921	76/197 (39%)
		Ion_trans_2	355..429	CDD:285168	31/74 (42%)
KCNS3	NP_001269357.1	BTB_2	17..116	CDD:280393	37/98 (38%)
		BTB	44..122	CDD:197585	28/78 (36%)
		Ion_trans	219..417	CDD:278921	77/205 (38%)
		Ion_trans_2	329..411	CDD:285168	35/84 (42%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820