Protein Alignment Shaw and KCNS2

DIOPT Version :9

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 136/427 - (31%)
• Similarity: 221/427 - (51%)
• Gaps: 38/427 - (8%)

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVF 77
            |.|.|:  ||||.:......||.:.|.|||.||         .|...:||.:..|::|||:|.:|
Human    16 DGEIRI--NVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78

  Fly    78 AQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDT 142
            ..||::|.|||||...::|...|.:|:|:||::...::.||..:|...:...|.....::.|.::
Human    79 PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQES 143

  Fly   143 EKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFC 207
            ...|.:|:   ..|..|..|.........:.::|...|.|..|..::...::|:..:..||::.|
Human   144 TTSSFDEI---LAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMC 205

  Fly   208 LKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKW 272
            |.:.||.::|        .:.|:.|         ....|..:|....||||||::.||..:|:..
Human   206 LNSLPDFQIP--------DSQGNPG---------EDPRFEIVEHFGIAWFTFELVARFAVAPDFL 253

  Fly   273 EFIKSSVNIIDYIATLSFYIDLVLQRFASH---LEN-ADILEFFSIIRIMRLFKLTRHSSGLKIL 333
            :|.|:::|:||.::.:.|||.||:......   |.| ..:.:...::||.|:.||.|||:||:.|
Human   254 KFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSL 318

  Fly   334 IQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDM 398
            ..|.:.|.||:.||:.:|.:||.||:.:.|   .|:...:....:||...|||.|:||||||||:
Human   319 GATLKYSYKEVGLLLLYLSVGISIFSVVAY---TIEKEENEGLATIPACWWWATVSMTTVGYGDV 380

  Fly   399 APKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            .|.|..|....:.|.|||:|.:.||:.:|.:.|:.:|
Human   381 VPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFY 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	38/106 (36%)
		BTB_2	27..117	CDD:280393	35/98 (36%)
		Ion_trans	244..439	CDD:278921	74/196 (38%)
		Ion_trans_2	355..429	CDD:285168	30/73 (41%)
KCNS2	NP_065748.1	BTB_2	19..118	CDD:308049	36/100 (36%)
		Ion_trans	186..421	CDD:306908	84/252 (33%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820