DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shaw and KCNQ3

DIOPT Version :10

Sequence 1:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_004510.1 Gene:KCNQ3 / 3786 HGNCID:6297 Length:872 Species:Homo sapiens


Alignment Length:386 Identity:93/386 - (24%)
Similarity:150/386 - (38%) Gaps:68/386 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 PGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL 138
            ||...||     |..|....|..|.|.   ||..|.|..|            |.|.:.:.:|.:.
Human    47 PGDVEQV-----TLALGAGADKDGTLL---LEGGGRDEGQ------------RRTPQGIGLLAKT 91

  Fly   139 DLDTEKPSEEELARKFGFEEDYYK--GTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICI 201
            .|  .:|.:...|:        |:  .|:.:....:||.|:|.   |.:         .||.|.:
Human    92 PL--SRPVKRNNAK--------YRRIQTLIYDALERPRGWALL---YHA---------LVFLIVL 134

  Fly   202 SILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFI 266
            ..|...:.|            |.|.....:|.:|...:|.| |..|..|.....| ......|:.
Human   135 GCLILAVLT------------TFKEYETVSGDWLLLLETFA-IFIFGAEFALRIW-AAGCCCRYK 185

  Fly   267 SSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLK 331
            ....:.:|.:..:.::|....::....:.:....:.|  |..|.....::|:|:.::.|.....|
Human   186 GWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVL--ATSLRSLRFLQILRMLRMDRRGGTWK 248

  Fly   332 ILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQP-------NPHNDFNSIPLGLWWALVT 389
            :|.....|.:|||....:...|.:::.:.|||..|:..|       ....:|.:....|||.|:|
Human   249 LLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLIT 313

  Fly   390 MTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRR 450
            :.|:||||..|||:.|..:.|..:|.||...|||..::.|..|:.... |.|.|..:|||:
Human   314 LATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQE-QHRQKHFEKRRK 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawNP_001137782.1 BTB_Shaw-like 24..135 CDD:349723 16/60 (27%)
Ion_trans 188..439 CDD:459842 60/257 (23%)
PRK14959 <418..>585 CDD:184923 11/33 (33%)
KCNQ3NP_004510.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Ion_trans 121..363 CDD:459842 63/270 (23%)
Selectivity filter. /evidence=ECO:0000250 316..321 3/4 (75%)
Mediates interaction with calmodulin. /evidence=ECO:0000269|PubMed:27564677 356..537 7/19 (37%)
KCNQ_channel 446..650 CDD:460954
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..611
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..872
KCNQC3-Ank-G_bd 770..866 CDD:463411
Blue background indicates that the domain is not in the aligned region.

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