DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and KCNQ3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_004510.1	Gene:	KCNQ3 / 3786	HGNCID:	6297	Length:	872	Species:	Homo sapiens

Alignment Length:	386	Identity:	93/386 - (24%)
Similarity:	150/386 - (38%)	Gaps:	68/386 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL 138
            ||...||     |..|....|..|.|.   ||..|.|..|            |.|.:.:.:|.:.
Human    47 PGDVEQV-----TLALGAGADKDGTLL---LEGGGRDEGQ------------RRTPQGIGLLAKT 91

  Fly   139 DLDTEKPSEEELARKFGFEEDYYK--GTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICI 201
            .|  .:|.:...|:        |:  .|:.:....:||.|:|.   |.:         .||.|.:
Human    92 PL--SRPVKRNNAK--------YRRIQTLIYDALERPRGWALL---YHA---------LVFLIVL 134

  Fly   202 SILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFI 266
            ..|...:.|            |.|.....:|.:|...:|.| |..|..|.....| ......|:.
Human   135 GCLILAVLT------------TFKEYETVSGDWLLLLETFA-IFIFGAEFALRIW-AAGCCCRYK 185

  Fly   267 SSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLK 331
            ....:.:|.:..:.::|....::....:.:....:.|  |..|.....::|:|:.::.|.....|
Human   186 GWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVL--ATSLRSLRFLQILRMLRMDRRGGTWK 248

  Fly   332 ILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQP-------NPHNDFNSIPLGLWWALVT 389
            :|.....|.:|||....:...|.:::.:.|||..|:..|       ....:|.:....|||.|:|
Human   249 LLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLIT 313

  Fly   390 MTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRR 450
            :.|:||||..|||:.|..:.|..:|.||...|||..::.|..|:.... |.|.|..:|||:
Human   314 LATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQE-QHRQKHFEKRRK 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	14/50 (28%)
		BTB_2	27..117	CDD:280393	14/42 (33%)
		Ion_trans	244..439	CDD:278921	49/201 (24%)
		Ion_trans_2	355..429	CDD:285168	27/80 (34%)
KCNQ3	NP_004510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Ion_trans	139..363	CDD:278921	56/240 (23%)
		Ion_trans_2	269..353	CDD:285168	28/83 (34%)
		Selectivity filter. /evidence=ECO:0000250	316..321		3/4 (75%)
		Mediates interaction with calmodulin. /evidence=ECO:0000269\|PubMed:27564677	356..537		7/19 (37%)
		KCNQ_channel	452..656	CDD:281513
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..611
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..872
		KCNQC3-Ank-G_bd	780..866	CDD:288784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810