DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNQ2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens

Alignment Length:	433	Identity:	99/433 - (22%)
Similarity:	162/433 - (37%)	Gaps:	94/433 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 KPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLD 236
            :||.|:.....|         |..:.|.|:.:..|.               |:|
Human    87 RPRGWAFIYHAY---------VFLLVFSCLVLSVFS---------------TIK----------- 116

  Fly   237 KTQTNAHIAFFYIECVCNAWFTFEILVRFISS---------PNKWEFIKSSVNIIDYIATLSFYI 292
            :.:.::..|.:.:|.|....|..|..||..::         ..:.:|.:....:|| |..|...|
Human   117 EYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVID-IMVLIASI 180

  Fly   293 DLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVI 357
            .::......::.....|.....::|:|:.::.|.....|:|.....|.:|||....:...|.:::
Human   181 AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLIL 245

  Fly   358 FASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIAL 422
            .:.|||.||:.: |.|  |::....|||.|:|:||:||||..|:|:.|..:.|...|.||...||
Human   246 ASFLVYLAEKGE-NDH--FDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFAL 307

  Fly   423 PVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPHSGPMGSG 487
            |..::.|.||:.... |.|.|..:|||                        .|.:|.........
Human   308 PAGILGSGFALKVQE-QHRQKHFEKRR------------------------NPAAGLIQSAWRFY 347

  Fly   488 GTGPRRMN--------NKTKDLVSPKSVAQLFAGPLGASIVAMSPRTMLDL------NPALAMGK 538
            .|...|.:        .:|..:....|..|.:    |||.: :.|...|:|      ...||..|
Human   348 ATNLSRTDLHSTWQYYERTVTVPMYSSQTQTY----GASRL-IPPLNQLELLRNLKSKSGLAFRK 407

  Fly   539 -PTFQPRIPTPLAATPPPPVSSAGGMTASGIGTTSATGATSAP 580
             |..:|. |:...:......||..|:.|.|.|:..|.....:|
Human   408 DPPPEPS-PSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSP 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	56/203 (28%)
		Ion_trans_2	355..429	CDD:285168	29/73 (40%)
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	63/271 (23%)
		KCNQ_channel	448..669	CDD:397540	1/2 (50%)
		KCNQ2_u3	684..774	CDD:406935
		KCNQC3-Ank-G_bd	786..886	CDD:403240
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810