DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNQ1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_000209.2	Gene:	KCNQ1 / 3784	HGNCID:	6294	Length:	676	Species:	Homo sapiens

Alignment Length:	236	Identity:	59/236 - (25%)
Similarity:	106/236 - (44%)	Gaps:	30/236 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 FYIECVCNAWFTFEILVRFISSPNK------W---EFIKSSVNIIDYIATLSFYIDLVL----QR 298
            |::|.|...:|..|.:||..|:..:      |   .|.:..::|||.|..::..:.|.:    |.
Human   157 FWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQV 221

  Fly   299 FASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVY 363
            ||:     ..:.....::|:|:..:.|.....::|........:||...::...||::..:..||
Human   222 FAT-----SAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVY 281

  Fly   364 YAER--IQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPV 426
            .||:  :..:...:|.|....|||.:||:||:||||..|:|::|..:.:..::..:...|||..:
Human   282 LAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGI 346

  Fly   427 IVSNFAMYYSHTQ----------ARAKLPKKRRRVLPVEQP 457
            :.|.||:.....|          |.|.|.:...|....|.|
Human   347 LGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	52/206 (25%)
		Ion_trans_2	355..429	CDD:285168	23/75 (31%)
KCNQ1	NP_000209.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..84
		Ion_trans	153..359	CDD:278921	52/206 (25%)
		Ion_trans_2	270..349	CDD:285168	25/78 (32%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		Interaction with CALM. /evidence=ECO:0000269\|PubMed:25441029	370..382		4/11 (36%)
		KCNQ_channel	<511..617	CDD:281513
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000269\|PubMed:25441029	515..529
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000269\|PubMed:25037568	535..572
		Interaction with AKAP9. /evidence=ECO:0000269\|PubMed:11799244	588..616
		C-terminal assembly domain. /evidence=ECO:0000269\|PubMed:10654932	589..620
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..676
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810