DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNK3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_002237.1	Gene:	KCNK3 / 3777	HGNCID:	6278	Length:	394	Species:	Homo sapiens

Alignment Length:	283	Identity:	58/283 - (20%)
Similarity:	91/283 - (32%)	Gaps:	89/283 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 FEILVRFI--SSPNK----WEFIKSSVNIIDYIATLS----------------FY----IDLVLQ 297
            :|.|.|.:  ..|:|    |.|..|....|..|.|:.                ||    |.|.|.
Human    59 YEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLV 123

  Fly   298 RFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFF-----LVLGIVI 357
            .|.|..|           ||..|.:...|.:...:.::....|...:.|:.||     |.:|...
Human   124 MFQSLGE-----------RINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAA 177

  Fly   358 FASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMA-----------PKTYIGMFVGAL 411
            |:             |.:..:.....::..:|:||:|:||..           |:.....||
Human   178 FS-------------HYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFV--- 226

  Fly   412 CALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTPG 476
            ..|.|:..|...:.::|..|....:..:.|   ..:.|.:|            ...|.:|.|..|
Human   227 YILTGLTVIGAFLNLVVLRFMTMNAEDEKR---DAEHRALL------------TRNGQAGGGGGG 276

  Fly   477 SGPH-----SGPMGSGGTGPRRM 494
            ...|     |....:||.|.|.:
Human   277 GSAHTTDTASSTAAAGGGGFRNV 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	45/221 (20%)
		Ion_trans_2	355..429	CDD:285168	14/84 (17%)
KCNK3	NP_002237.1	Ion_trans_2	<77..132	CDD:400301	14/65 (22%)
		Ion_trans_2	167..247	CDD:400301	17/95 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..286		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000