DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNK1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_002236.1	Gene:	KCNK1 / 3775	HGNCID:	6272	Length:	336	Species:	Homo sapiens

Alignment Length:	253	Identity:	46/253 - (18%)
Similarity:	88/253 - (34%)	Gaps:	81/253 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 ANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSS---------VNII 282
            :|.|..|..|.|.     |.|:...|             :|:......:..|         .::|
Human    94 SNASGNWNWDFTS-----ALFFASTV-------------LSTTGYGHTVPLSDGGKAFCIIYSVI 140

  Fly   283 DYIATLSFYIDLVLQRFASHLENADILEF-----FSIIRIMRLFKLTRHSSGLKILIQTFRASAK 342
            ....||.| :..|:||...|:....:|.|     ||                            |
Human   141 GIPFTLLF-LTAVVQRITVHVTRRPVLYFHIRWGFS----------------------------K 176

  Fly   343 ELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAP-KTYIGM 406
            ::..:|..::||.|..:...:....:.....:|:|.:. ..::..::::|:|.||..| :.|...
Human   177 QVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLE-SFYFCFISLSTIGLGDYVPGEGYNQK 240

  Fly   407 F-----VGALC-ALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPR 458
            |     :|..| .|.|::.:.    |::..|...:.        .||.|::..|::.:
Human   241 FRELYKIGITCYLLLGLIAML----VVLETFCELHE--------LKKFRKMFYVKKDK 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	37/215 (17%)
		Ion_trans_2	355..429	CDD:285168	15/80 (19%)
KCNK1	NP_002236.1	Ion_trans_2	<101..157	CDD:400301	14/74 (19%)
		pore-forming domain	107..123		4/28 (14%)
		Ion_trans_2	192..267	CDD:400301	14/79 (18%)
		pore-forming domain	212..238		5/26 (19%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269\|PubMed:19959478	293..299
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000