DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNF1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_002227.2	Gene:	KCNF1 / 3754	HGNCID:	6246	Length:	494	Species:	Homo sapiens

Alignment Length:	523	Identity:	165/523 - (31%)
Similarity:	242/523 - (46%)	Gaps:	98/523 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALA-----------NYDPILNEYFFDRHPGVFAQV 80
            :|:||||:|...|...|.:.|.|||:.|...||           :|||...|::|||.|..|..|
Human    25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCV 89

  Fly    81 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLA-----VLDRLDL 140
            :..|..|::|....:|...|:.|::||.:|...::.||....::.|:..|.:|     :||.|.:
Human    90 IEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGV 154

  Fly   141 DTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILS 205
            |..:                     ..|:..:..:|...::|.||..|:.:.|:|...|.:|.:.
Human   155 DAAE---------------------GRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVV 198

  Fly   206 FCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNA-HIAFFYIECVCNAWFTFEILVRFISSP 269
            .|:.|.|:::|                  ||...... |.....:|..|..|||.|.|:|..|||
Human   199 MCMGTIPELQV------------------LDAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSP 245

  Fly   270 NKWEFIKSSVNIIDYIATLSFYIDLVLQRFAS---HLENA-DILEFFSIIRIMRLFKLTRHSSGL 330
            ||..|..|.:||:|.:|.|.||:.|.|....:   .|.|. ..::...|:||.|:|||.||||||
Human   246 NKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGL 310

  Fly   331 KILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGY 395
            :.|....:.|.|||.||:.:|.:||.:|::|.|..|  |.:|...|.|||...|||::|||||||
Human   311 QTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTME--QSHPETLFKSIPQSFWWAIITMTTVGY 373

  Fly   396 GDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQP 460
            ||:.|||.:|....|:..|.||:.||||:..|::||..||:           ::|||......:.
Human   374 GDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYN-----------KQRVLETAAKHEL 427

  Fly   461 RLPGAPGGVSGCGTPGSGPHSGPMGSGGTGPRRMNNKTKDLVSPKSVAQLFAGPLGASIVAMSPR 525
            .|...              :|...|.|.||..|.:   .|.:.|:        |.|....:.|.|
Human   428 ELMEL--------------NSSSGGEGKTGGSRSD---LDNLPPE--------PAGKEAPSCSSR 467

  Fly   526 TML 528
            ..|
Human   468 LKL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	36/108 (33%)
		BTB_2	27..117	CDD:280393	34/100 (34%)
		Ion_trans	244..439	CDD:278921	88/198 (44%)
		Ion_trans_2	355..429	CDD:285168	36/73 (49%)
KCNF1	NP_002227.2	BTB_POZ_Kv5_KCNF1	23..138	CDD:349690	37/112 (33%)
		Ion_trans	181..417	CDD:395416	100/266 (38%)
		Selectivity filter. /evidence=ECO:0000250	370..375		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..469		12/46 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820