DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and KCND2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_036413.1	Gene:	KCND2 / 3751	HGNCID:	6238	Length:	630	Species:	Homo sapiens

Alignment Length:	634	Identity:	188/634 - (29%)
Similarity:	280/634 - (44%)	Gaps:	164/634 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHY 91
            :||||.|.|.:|::.||::.|.|.|.. :|....|.|...:|||||.|.:|..:||:||||||||
Human    43 IVLNVSGTRFQTWQDTLERYPDTLLGS-SERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHY 106

  Fly    92 PTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL--DLDTEKPSEEELARKF 154
            |...|...::|||.|:||....:..||   |.:::|.:...|  :||  |.||:...|..|..
Human   107 PRHECISAYDEELAFFGLIPEIIGDCC---YEEYKDRRRENA--ERLQDDADTDTAGESALPT-- 164

  Fly   155 GFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIV 219
                          ...:.|:|..|:.|::|..|.....|:.|||.:|:::..::|.|
Human   165 --------------MTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP------- 208

  Fly   220 RNITVKTANGSNGWFLDKTQTNAH--IAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNII 282
                    .||:...:.:......  :|||.::..|...||.|.|:|..::|:::.|::|.::||
Human   209 --------CGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSII 265

  Fly   283 DYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAKEL 344
            |.:|.|.:||.||:      .:|.|:...|   .:.|:.|:||.:|||.||:||..|.::.|.||
Human   266 DVVAILPYYIGLVM------TDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL 324

  Fly   345 TLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVG 409
            ..|:|.|.:.|:|||::::|||:  .:..:.|.|||...|:.:|||||:|||||.|||..|...|
Human   325 GFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFG 387

  Fly   410 ALCALAGVLTIALPVPVIVSNFAMYYSHTQ-----------------------ARAKLPKKRR-- 449
            ::|:|:|||.||||||||||||:..|...|                       |.|.:..||.
Human   388 SICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGL 452

  Fly   450 ----------------------------------------------------RVLPVEQP--RQP 460
                                                                .|..|.:|  ..|
Human   453 LSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSP 517

  Fly   461 RLPGAPGGVSGCGT---------PG---SGPHSGPMGSGGTGPRRMNNKTKDLVSPKSVAQLFAG 513
            .|....|..|.|.:         |.   ||.|.|.:....|...|...:|
Human   518 SLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHQGSIQELSTIQIRCVERT--------------- 567

  Fly   514 PLGASIVAMSPRTMLDLNPALAMGKPTFQPRIPTPLAATPPPPVSSAGG 562
            ||..|      |:.|:......:.....||.:.|.:.:.|.|||::..|
Human   568 PLSNS------RSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEG 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	43/97 (44%)
		BTB_2	27..117	CDD:280393	40/89 (45%)
		Ion_trans	244..439	CDD:278921	87/197 (44%)
		Ion_trans_2	355..429	CDD:285168	40/73 (55%)
KCND2	NP_036413.1	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250\|UniProtKB:Q63881	2..20
		Shal-type	3..28	CDD:288455
		BTB_2	43..132	CDD:308049	40/89 (45%)
		Interaction with KCNIP1. /evidence=ECO:0000250\|UniProtKB:Q63881	71..90		8/18 (44%)
		Ion_trans	184..415	CDD:306908	97/253 (38%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	308..321		5/12 (42%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		3/4 (75%)
		DUF3399	445..546	CDD:314709	11/100 (11%)
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250\|UniProtKB:Q63881, ECO:0000305\|PubMed:16934482	474..630		29/158 (18%)
		Required for dendritic targeting. /evidence=ECO:0000250\|UniProtKB:Q63881	474..489		0/14 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	600..630		5/11 (45%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q63881	627..630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810