DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and KCND1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_024308146.1	Gene:	KCND1 / 3750	HGNCID:	6237	Length:	675	Species:	Homo sapiens

Alignment Length:	676	Identity:	210/676 - (31%)
Similarity:	293/676 - (43%)	Gaps:	176/676 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHY 91
            :|:||.|.|.||:|.||.:.|.|.|.. :|....||....||||||.|.:|..|||:||||:||.
Human    42 LVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHC 105

  Fly    92 PTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKFGF 156
            |...|...|:|||.|:||....|..||...|.            ||...:.|:.:|:|.|.:.|.
Human   106 PRQECIQAFDEELAFYGLVPELVGDCCLEEYR------------DRKKENAERLAEDEEAEQAGD 158

  Fly   157 EEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRN 221
            ......|:     .::.|:|..|:.|::|.||.....|:.|||.:|:::..::|.|
Human   159 GPALPAGS-----SLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP--------- 209

  Fly   222 ITVKTANGSNGWFLDKTQTNAHI--AFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDY 284
                 ..||......:.......  |||.::..|...||.|.|:|..::|::..|::|.:::||.
Human   210 -----CRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDV 269

  Fly   285 IATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAKELTL 346
            :|.|.:||.|::.:      |.|:...|   .:.|:.|:||.:|||.||:||..|.::.|.||..
Human   270 VAILPYYIGLLVPK------NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGF 328

  Fly   347 LVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGAL 411
            |:|.|.:.|:|||::::|||: ..|..| |.|||...|:.:|||||:|||||.|.|..|...|::
Human   329 LLFSLTMAIIIFATVMFYAEK-GTNKTN-FTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSI 391

  Fly   412 CALAGVLTIALPVPVIVSNFAMYYSHTQ-------------ARAKLPK----------KRRRVLP 453
            |:|:|||.||||||||||||:..|...|             ||.:|.|          |:...|.
Human   392 CSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLE 456

  Fly   454 V---------------------------------------------EQPRQPRLP---------- 463
            |                                             ||.....|.
Human   457 VGRGLDRVGVSHNGEEGAALIALLHLLQDSGSGEEQALCVRNRSAFEQQHHHLLHCLEKTTCHEF 521

  Fly   464 ----------GA--PGGVSGCGTPGSGPHSGPMGSG----GTGPRRMNNKTKDLV-SPKSVAQ-- 509
                      ||  |||.:...|..|   |.|:|.|    ...|||...:...|. |..||::
Human   522 TDELTFSEALGAVSPGGRTSRSTSVS---SQPVGPGSLLSSCCPRRAKRRAIRLANSTASVSRGS 583

  Fly   510 -----LFAG------PLGASIVAMSPRTMLDLN-------PALAMGKPTFQPRIPTPLAATP--P 554
                 :.||      |...|.:...|...||||       .|:.        .||||.|.||  .
Human   584 MQELDMLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAII--------SIPTPPANTPDES 640

  Fly   555 PPVSSAGGMTASGIGTTSATGATSAP 580
            .|.|..||..|   |:|....:...|
Human   641 QPSSPGGGGRA---GSTLRNSSLGTP 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	46/97 (47%)
		BTB_2	27..117	CDD:280393	43/89 (48%)
		Ion_trans	244..439	CDD:278921	86/199 (43%)
		Ion_trans_2	355..429	CDD:285168	41/73 (56%)
KCND1	XP_024308146.1	Shal-type	3..28	CDD:288455
		BTB_2	42..131	CDD:308049	43/89 (48%)
		Ion_trans	185..417	CDD:306908	96/253 (38%)
		DUF3399	447..578	CDD:314709	22/133 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810