DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNC4

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_024302558.1	Gene:	KCNC4 / 3749	HGNCID:	6236	Length:	661	Species:	Homo sapiens

Alignment Length:	483	Identity:	231/483 - (47%)
Similarity:	308/483 - (63%)	Gaps:	51/483 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILN---------------EYFFD 71
            ::..::::||||.|||||::||:.:|.|||:.|.:......|..:               |:|||
Human    33 EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

  Fly    72 RHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLD 136
            |||||||.|||||||||||.|.|||||||||||.|||:|...|||||||||.||||.:|.|.:.:
Human    98 RHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFE 162

  Fly   137 RLD--------LDTEKPSEEELA-RKFGFEE-----DYYKGTISWWQEMKPRIWSLFDEPYSSNA 187
            ..|        .|.....|.||| ::.|..|     ....|....||   ||:|:||::||||.|
Human   163 SPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQ---PRMWALFEDPYSSRA 224

  Fly   188 AKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNIT--VKTANGSNGWFLDKTQTNAHIAFFYIE 250
            |:.:...|:|||.:||.:|||:||....:.  ||:|  ::..|.::..|..:.:|...:.  |||
Human   225 ARVVAFASLFFILVSITTFCLETHEAFNID--RNVTEILRVGNITSVHFRREVETEPILT--YIE 285

  Fly   251 CVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSI- 314
            .||..|||.|.|||.:..|:..:|:|:.:||||::|.|.||:::.|...:|.... |:|.|..:
Human   286 GVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAAR-DVLGFLRVV 349

  Fly   315 --IRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERI-------QP 370
              :||:|:||||||..||::|..|.|||..|..||:.||.||::|||:::||||||       :.
Human   350 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRG 414

  Fly   371 NPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            |.|.||.:||:|.|||:|||||:|||||.|||:.||.||||||||||||||:||||||:||.|||
Human   415 NDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479

  Fly   436 SHTQARAKLPKKRRRVLPVEQPRQPRLP 463
            |...|:.||||||::.:|  :|.|...|
Human   480 SLAMAKQKLPKKRKKHVP--RPAQLESP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	64/112 (57%)
		BTB_2	27..117	CDD:280393	57/104 (55%)
		Ion_trans	244..439	CDD:278921	111/204 (54%)
		Ion_trans_2	355..429	CDD:285168	53/80 (66%)
KCNC4	XP_024302558.1	Potassium_chann	1..29	CDD:314363
		BTB_2	38..143	CDD:308049	57/104 (55%)
		Ion_trans	225..483	CDD:306908	129/262 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2063
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1570
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48788
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40911
orthoMCL	1	0.900	-	-		OOG6_102927
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3268
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870