Protein Alignment Shaw and KCNC4

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_024302558.1
• Gene: KCNC4 / 3749
• HGNCID: 6236
• Length: 661
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 231/483 - (47%)
• Similarity: 308/483 - (63%)
• Gaps: 51/483 - (10%)

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILN---------------EYFFD 71
            ::..::::||||.|||||::||:.:|.|||:.|.:......|..:               |:|||
Human    33 EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

  Fly    72 RHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLD 136
            |||||||.|||||||||||.|.|||||||||||.|||:|...|||||||||.||||.:|.|.:.:
Human    98 RHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFE 162

  Fly   137 RLD--------LDTEKPSEEELA-RKFGFEE-----DYYKGTISWWQEMKPRIWSLFDEPYSSNA 187
            ..|        .|.....|.||| ::.|..|     ....|....||   ||:|:||::||||.|
Human   163 SPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQ---PRMWALFEDPYSSRA 224

  Fly   188 AKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNIT--VKTANGSNGWFLDKTQTNAHIAFFYIE 250
            |:.:...|:|||.:||.:|||:||....:.  ||:|  ::..|.::..|..:.:|...:.  |||
Human   225 ARVVAFASLFFILVSITTFCLETHEAFNID--RNVTEILRVGNITSVHFRREVETEPILT--YIE 285

  Fly   251 CVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSI- 314
            .||..|||.|.|||.:..|:..:|:|:.:||||::|.|.||:::.|...:|.... |:|.|..:
Human   286 GVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAAR-DVLGFLRVV 349

  Fly   315 --IRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERI-------QP 370
              :||:|:||||||..||::|..|.|||..|..||:.||.||::|||:::||||||       :.
Human   350 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRG 414

  Fly   371 NPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            |.|.||.:||:|.|||:|||||:|||||.|||:.||.||||||||||||||:||||||:||.|||
Human   415 NDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 479

  Fly   436 SHTQARAKLPKKRRRVLPVEQPRQPRLP 463
            |...|:.||||||::.:|  :|.|...|
Human   480 SLAMAKQKLPKKRKKHVP--RPAQLESP 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	70/125 (56%)
		Ion_trans	188..439	CDD:459842	129/262 (49%)
		PRK14959	<418..>585	CDD:184923	27/46 (59%)
KCNC4	XP_024302558.1	Potassium_chann	1..29	CDD:431870
		BTB_KCNC2_4	35..158	CDD:349722	69/122 (57%)
		Ion_trans	225..483	CDD:459842	129/262 (49%)