DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNC2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_631875.1	Gene:	KCNC2 / 3747	HGNCID:	6234	Length:	638	Species:	Homo sapiens

Alignment Length:	503	Identity:	239/503 - (47%)
Similarity:	314/503 - (62%)	Gaps:	78/503 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MDSENRVVLNVGGIRHETYKATLKKIPATRLSRLT-------------EALANYDPILN------ 66
            :::..||:|||||.|||||::|||.:|.|||:.|.             :.|....|.|:
Human     4 IENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAP 68

  Fly    67 --------------------------------EYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPL 99
                                            |:||||||||||.|||||||||||.|.||||||
Human    69 PLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPL 133

  Fly   100 FEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEE--LARKFGFEE---- 158
            |||||.|||:|...|||||||||.||||.:|.|.:.:..||....|.::|  .|::.|.|:
Human   134 FEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGL 198

  Fly   159 ---DYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVR 220
               |   |....|:.::||:|:||::||||.||:.|...|:|||.:||.:|||:||....  ||:
Human   199 GGPD---GKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFN--IVK 258

  Fly   221 NITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYI 285
            |.|....||::.....:.:|:.  |..|:|.||..|||||.|||.:.||||.||||:.:||||::
Human   259 NKTEPVINGTSVVLQYEIETDP--ALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFV 321

  Fly   286 ATLSFYIDLVLQRFASHLENADILEFFSI---IRIMRLFKLTRHSSGLKILIQTFRASAKELTLL 347
            |.|.||:::.|...:|.... |:|.|..:   :||:|:||||||..||::|..|.|||..|..||
Human   322 AILPFYLEVGLSGLSSKAAK-DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLL 385

  Fly   348 VFFLVLGIVIFASLVYYAERI--QPN-----PHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIG 405
            :.||.||::|||:::|||||:  |||     .|..|.:||:|.|||:|||||:|||||.|:|:.|
Human   386 IIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSG 450

  Fly   406 MFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLP 453
            |.||||||||||||||:||||||:||.||||...|:.|||:||::.:|
Human   451 MLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	69/148 (47%)
		BTB_2	27..117	CDD:280393	62/140 (44%)
		Ion_trans	244..439	CDD:278921	116/204 (57%)
		Ion_trans_2	355..429	CDD:285168	52/80 (65%)
KCNC2	NP_631875.1	BTB_KCNC2_4	7..166	CDD:349722	75/158 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..93		3/54 (6%)
		Ion_trans	228..484	CDD:395416	136/260 (52%)
		Selectivity filter. /evidence=ECO:0000250	437..442		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2063
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71199
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1570
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48788
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	1	1.000	-	-		otm40911
orthoMCL	1	0.900	-	-		OOG6_102927
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3268
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870