DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNC1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001106212.1	Gene:	KCNC1 / 3746	HGNCID:	6233	Length:	585	Species:	Homo sapiens

Alignment Length:	488	Identity:	244/488 - (50%)
Similarity:	323/488 - (66%)	Gaps:	41/488 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALA----NYDPILNEYFFDRHPGVFAQVLN 82
            |...|:|:||||.||:||::||:.:|.|||:.|.|..|    :|||..:|:||||||||||.:||
Human     5 DESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILN 69

  Fly    83 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETL-----AVLDRL--DL 140
            ||||||||.|.||||||:||||.|||:|...|||||||||.||||.:|.|     |.||..  |.
Human    70 YYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDA 134

  Fly   141 DTEKP-------SEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFF 198
            |.:.|       .|.|:.::....:........:|:..:||||:||::||||..|:.:...|:||
Human   135 DADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFF 199

  Fly   199 ICISILSFCLKTHPDMRVPIVRNITVKTA-NGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEIL 262
            |.:||.:|||:||.... |||....::.. ||:...:..:.:|.|.:.  |||.||..|||||.|
Human   200 ILVSITTFCLETHERFN-PIVNKTEIENVRNGTQVRYYREAETEAFLT--YIEGVCVVWFTFEFL 261

  Fly   263 VRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSI---IRIMRLFKLT 324
            :|.|..|||.||||:|:||||::|.|.||:::.|...:|.... |:|.|..:   :||:|:||||
Human   262 MRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAK-DVLGFLRVVRFVRILRIFKLT 325

  Fly   325 RHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERI--QPN-----PHNDFNSIPLG 382
            ||..||::|..|.|||..|..||:.||.||::|||:::||||||  |||     .|..|.:||:|
Human   326 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIG 390

  Fly   383 LWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKK 447
            .|||:|||||:|||||.|:|:.||.||||||||||||||:||||||:||.||||...|:.|||||
Human   391 FWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKK 455

  Fly   448 RRRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPH 480
            :::.:    ||.|:| |:|   :.|.:..:.||
Human   456 KKKHI----PRPPQL-GSP---NYCKSVVNSPH 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	66/101 (65%)
		BTB_2	27..117	CDD:280393	59/93 (63%)
		Ion_trans	244..439	CDD:278921	117/204 (57%)
		Ion_trans_2	355..429	CDD:285168	53/80 (66%)
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721	73/115 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..147		6/25 (24%)
		Ion_trans	189..447	CDD:395416	136/261 (52%)
		Selectivity filter. /evidence=ECO:0000250	400..405		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2063
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1570
Isobase	1	0.950	-	0	Normalized mean entropy	S3401
OMA	1	1.010	-	-		QHG48788
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	1	1.000	-	-		otm40911
orthoMCL	1	0.900	-	-		OOG6_102927
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3268
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820