DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNA10

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_005540.1	Gene:	KCNA10 / 3744	HGNCID:	6219	Length:	511	Species:	Homo sapiens

Alignment Length:	472	Identity:	177/472 - (37%)
Similarity:	261/472 - (55%)	Gaps:	61/472 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT 86
            :...||::|:.|:|.||...||.:.|.|.|....:.:..:|.:.|||||||:...|..:|.||::
Human    83 EGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQS 147

  Fly    87 -GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEEL 150
             ||:..|.:|...:|.:|:.|:.|.|..::        |.|:.:..:.     |.:|..|: .::
Human   148 GGKIRRPANVPIDIFADEISFYELGSEAMD--------QFREDEGFIK-----DPETLLPT-NDI 198

  Fly   151 ARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMR 215
            .|:|                     |.||:.|.||:||:.:.||||..:.|||..|||:|.|:.|
Human   199 HRQF---------------------WLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFR 242

  Fly   216 ----VPIVR--NITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEF 274
                :.:||  |:.:.....|...|.|        .||.:|..|..|||||:::||:..|:|.:|
Human   243 EDRELKVVRDPNLNMSKTVLSQTMFTD--------PFFMVESTCIVWFTFELVLRFVVCPSKTDF 299

  Fly   275 IKSSVNIIDYIATLSFY----IDLVLQRFASHLENAD--ILEFFSIIRIMRLFKLTRHSSGLKIL 333
            .::.:||||.|:.:.::    .:||.:...|..:|..  ||....::|:.|:|||:|||.||:||
Human   300 FRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQIL 364

  Fly   334 IQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDM 398
            .||.:||.:||.||:|||.:|:::|:|.||:||..:|..|  |:|||.|.|||:|||||||||||
Human   365 GQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESH--FSSIPDGFWWAVVTMTTVGYGDM 427

  Fly   399 APKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY---SHTQARAKLPKKRRRVLPVEQPRQP 460
            .|.|..|..||.|||:|||||||||||||||||..:|   :..:.:..:|.:..|:|.....|..
Human   428 CPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMG 492

  Fly   461 RLPGAPGGVSGCGTPGS 477
            ..........||.|..|
Human   493 STDSLNKTNGGCSTEKS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	32/98 (33%)
		BTB_2	27..117	CDD:280393	32/90 (36%)
		Ion_trans	244..439	CDD:278921	102/203 (50%)
		Ion_trans_2	355..429	CDD:285168	48/73 (66%)
KCNA10	NP_005540.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..50
		BTB_2	88..179	CDD:308049	32/98 (33%)
		Ion_trans	255..467	CDD:306908	105/221 (48%)
		Selectivity filter. /evidence=ECO:0000250	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..511		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810