DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shaw and KCNA7

DIOPT Version :9

Sequence 1:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_114092.2 Gene:KCNA7 / 3743 HGNCID:6226 Length:456 Species:Homo sapiens


Alignment Length:481 Identity:188/481 - (39%)
Similarity:250/481 - (51%) Gaps:83/481 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTG--- 87
            |:||||.|:|.||...||.:.|.|.|.........||....|||||||...|..||.||::|   
Human    14 RLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRL 78

  Fly    88 --KLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL--DLDTEKPSEE 148
              ..|.|.||    |.||:.|:||.:                     |.|.||  |.....|.|.
Human    79 RRPAHVPLDV----FLEEVAFYGLGA---------------------AALARLREDEGCPVPPER 118

  Fly   149 ELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPD 213
            .|.|:                ....::|.||:.|.||.||:.:.||||..|.:||:.|||:|.||
Human   119 PLPRR----------------AFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPD 167

  Fly   214 MRVPIVRNITVKTA-----------NGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFIS 267
            .|..  |:.|...|           |||:....:..:...:..||.:|.:|..||:||:|||.:.
Human   168 FRDD--RDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCICWFSFELLVRLLV 230

  Fly   268 SPNKWEFIKSSVNIIDYIATLSFYI----DLVLQR-FASHLENADILEFFSIIRIMRLFKLTRHS 327
            .|:|..|.|:.:|:||::|.|.:::    :|..|| ......:..||....::|:.|:|||:|||
Human   231 CPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRHS 295

  Fly   328 SGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTT 392
            .||:||.||.|||.:||.||:|||.:|:|:|:|.||:||..:.:.|  |.|||...|||:|||||
Human   296 KGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSH--FTSIPESFWWAVVTMTT 358

  Fly   393 VGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY------------SHTQARAKLP 445
            ||||||||.|..|..||:|||:||||||:||||||||||:.:|            ||...:...|
Human   359 VGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQPCGP 423

  Fly   446 ---KKRRRVLPVEQPRQPRLPGAPGG 468
               |....::..|.|..|....||.|
Human   424 LEGKANGGLVDGEVPELPPPLWAPPG 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawNP_001137782.1 BTB 27..125 CDD:197585 38/102 (37%)
BTB_2 27..117 CDD:280393 38/94 (40%)
Ion_trans 244..439 CDD:278921 104/211 (49%)
Ion_trans_2 355..429 CDD:285168 47/73 (64%)
KCNA7NP_114092.2 BTB_2 15..105 CDD:280393 40/114 (35%)
BTB 15..98 CDD:197585 36/86 (42%)
Ion_trans 200..404 CDD:278921 102/205 (50%)
Ion_trans_2 319..398 CDD:285168 52/80 (65%)
Selectivity filter. /evidence=ECO:0000250 358..363 4/4 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D818306at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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