DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shaw and KCNA4

DIOPT Version :10

Sequence 1:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_002224.1 Gene:KCNA4 / 3739 HGNCID:6222 Length:653 Species:Homo sapiens


Alignment Length:440 Identity:177/440 - (40%)
Similarity:243/440 - (55%) Gaps:71/440 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT 86
            |...|||:||.|:|.||...||.:.|.|.|....:....:||:.|||||||:...|..:|.||::
Human   173 DCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQS 237

  Fly    87 -GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEEL 150
             |:|..|.:|...:|.||::|:.|.                                     ||.
Human   238 GGRLKRPVNVPFDIFTEEVKFYQLG-------------------------------------EEA 265

  Fly   151 ARKF----GF---EEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCL 208
            ..||    ||   |||.....    .|.|.:||.||:.|.||:.|:.|.:|||..|.|||:.|||
Human   266 LLKFREDEGFVREEEDRALPE----NEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCL 326

  Fly   209 KTHPDMRVPIVRNITVKTANGSNGWFLDKT-----QTNAHI----AFFYIECVCNAWFTFEILVR 264
            :|.|:.|..  |::.:..:.|.:|..|:.|     :.:.|.    .||.:|.||..||:||.:||
Human   327 ETLPEFRDD--RDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVR 389

  Fly   265 FISSPNKWEFIKSSVNIIDYIATLSFYI----DLVLQRFASHLENAD-----ILEFFSIIRIMRL 320
            ..:.|::..|.|:.:||||.::.|.::|    ||..|:...:.:...     ||....::|:.|:
Human   390 CFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRI 454

  Fly   321 FKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWW 385
            |||:|||.||:||..|.|||.:||.||:|||.:|:::|:|.||:||..:|..|  |.|||...||
Human   455 FKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTH--FQSIPDAFWW 517

  Fly   386 ALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            |:|||||||||||.|.|..|..||:|||:|||||||||||||||||..:|
Human   518 AVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawNP_001137782.1 BTB_Shaw-like 24..135 CDD:349723 36/111 (32%)
Ion_trans 188..439 CDD:459842 122/266 (46%)
PRK14959 <418..>585 CDD:184923 15/18 (83%)
KCNA4NP_002224.1 K_channel_TID 1..>37 CDD:429748
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..148
BTB_POZ 176..303 CDD:453885 52/167 (31%)
Ion_trans 306..570 CDD:459842 122/266 (46%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 462..475 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 524..529 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..653
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P15385 651..653
Blue background indicates that the domain is not in the aligned region.

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