DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and KCNA4

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_002224.1	Gene:	KCNA4 / 3739	HGNCID:	6222	Length:	653	Species:	Homo sapiens

Alignment Length:	440	Identity:	177/440 - (40%)
Similarity:	243/440 - (55%)	Gaps:	71/440 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT 86
            |...|||:||.|:|.||...||.:.|.|.|....:....:||:.|||||||:...|..:|.||::
Human   173 DCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQS 237

  Fly    87 -GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEEL 150
             |:|..|.:|...:|.||::|:.|.                                     ||.
Human   238 GGRLKRPVNVPFDIFTEEVKFYQLG-------------------------------------EEA 265

  Fly   151 ARKF----GF---EEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCL 208
            ..||    ||   |||.....    .|.|.:||.||:.|.||:.|:.|.:|||..|.|||:.|||
Human   266 LLKFREDEGFVREEEDRALPE----NEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCL 326

  Fly   209 KTHPDMRVPIVRNITVKTANGSNGWFLDKT-----QTNAHI----AFFYIECVCNAWFTFEILVR 264
            :|.|:.|..  |::.:..:.|.:|..|:.|     :.:.|.    .||.:|.||..||:||.:||
Human   327 ETLPEFRDD--RDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVR 389

  Fly   265 FISSPNKWEFIKSSVNIIDYIATLSFYI----DLVLQRFASHLENAD-----ILEFFSIIRIMRL 320
            ..:.|::..|.|:.:||||.::.|.::|    ||..|:...:.:...     ||....::|:.|:
Human   390 CFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRI 454

  Fly   321 FKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWW 385
            |||:|||.||:||..|.|||.:||.||:|||.:|:::|:|.||:||..:|..|  |.|||...||
Human   455 FKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTH--FQSIPDAFWW 517

  Fly   386 ALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            |:|||||||||||.|.|..|..||:|||:|||||||||||||||||..:|
Human   518 AVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	35/98 (36%)
		BTB_2	27..117	CDD:280393	35/90 (39%)
		Ion_trans	244..439	CDD:278921	101/205 (49%)
		Ion_trans_2	355..429	CDD:285168	47/73 (64%)
KCNA4	NP_002224.1	K_channel_TID	1..>37	CDD:400339
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..148
		BTB_POZ	176..303	CDD:365784	52/167 (31%)
		Ion_trans	306..570	CDD:395416	122/266 (46%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	462..475		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	524..529		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..653
		PDZ-binding. /evidence=ECO:0000250	651..653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810