DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shaw and KCNA3

DIOPT Version :9

Sequence 1:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_002223.3 Gene:KCNA3 / 3738 HGNCID:6221 Length:575 Species:Homo sapiens


Alignment Length:515 Identity:178/515 - (34%)
Similarity:258/515 - (50%) Gaps:114/515 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKL 89
            |||:|:.|:|.||...||.:.|.|.|......:..:||:.|||||||:...|..:|.||:: |::
Human   105 RVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRI 169

  Fly    90 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKF 154
            ..|.:|...:|.||:.|:.|.                                     ||...||
Human   170 RRPVNVPIDIFSEEIRFYQLG-------------------------------------EEAMEKF 197

  Fly   155 GFEEDYYKGTISWWQEMKP--------RIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTH 211
            ..:|.:.:      :|.:|        ::|.||:.|.||..|:.|.:|||..|.|||:.|||:|.
Human   198 REDEGFLR------EEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETL 256

  Fly   212 PDMR-------------VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILV 263
            |:.|             .....|.|..:..|::. |.|        .||.:|.:|..||:||:||
Human   257 PEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASS-FSD--------PFFVVETLCIIWFSFELLV 312

  Fly   264 RFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENAD------ILEFFSIIRIMRLFK 322
            ||.:.|:|..|.::.:|:||.:|.:.::|.|..: .|....|..      ||....::|:.|:||
Human   313 RFFACPSKATFSRNIMNLIDIVAIIPYFITLGTE-LAERQGNGQQAMSLAILRVIRLVRVFRIFK 376

  Fly   323 LTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWAL 387
            |:|||.||:||.||.:||.:||.||:|||.:|:::|:|.||:||  ..:|.:.|:|||...|||:
Human   377 LSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--ADDPTSGFSSIPDAFWWAV 439

  Fly   388 VTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY----------------- 435
            |||||||||||.|.|..|..||:|||:|||||||||||||||||..:|                 
Human   440 VTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGS 504

  Fly   436 -SHTQARAKLPKKRR--------RVLPVEQPRQ-----PRLPGAPGGVSGCGTPGSGPHS 481
             .|..:.|:..:|.|        ..:.:|:...     |:.|...|..:...|..:.|:|
Human   505 CQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNS 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawNP_001137782.1 BTB 27..125 CDD:197585 33/98 (34%)
BTB_2 27..117 CDD:280393 33/90 (37%)
Ion_trans 244..439 CDD:278921 101/218 (46%)
Ion_trans_2 355..429 CDD:285168 46/73 (63%)
KCNA3NP_002223.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52
BTB 106..200 CDD:197585 37/130 (28%)
BTB_2 106..197 CDD:280393 35/127 (28%)
Ion_trans 290..490 CDD:278921 102/211 (48%)
Ion_trans_2 404..481 CDD:285168 49/78 (63%)
Selectivity filter. /evidence=ECO:0000250 444..449 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 573..575
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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