DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcnk5

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001034605.1	Gene:	Kcnk5 / 364241	RGDID:	1564985	Length:	503	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	96/493 - (19%)
Similarity:	153/493 - (31%)	Gaps:	183/493 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 IWSLFDEPYSSNAAKTIGVVSVF----FICIS------ILSFCLKTHPDMRVPIVRNITVKTANG 229
            |:.:.:||:...|.|......:.    |.|:|      ||. .:....|..|.|..|.|....|.
  Rat    22 IFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLSQEGLDKILQ-VVSDAADQGVAITGNQTFNNWNW 85

  Fly   230 SNGWFLDKT------------QTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNII 282
            .|......|            :|.|...|    ||....|...:.:.:||:..|
  Rat    86 PNAMIFAATVITTIGYGNVAPKTPAGRLF----CVFYGLFGVPLCLTWISALGK----------- 135

  Fly   283 DYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFK-LTRHSSGLKILIQTFRASAKELTL 346
                                        ||. .|..||.: |||....|:         ..::|.
  Rat   136 ----------------------------FFG-GRAKRLGQFLTRRGVSLR---------KAQITC 162

  Fly   347 LVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAP----------- 400
            ...|:|.|:::...:..:...:.    .::|.|. ||:::.:|::|:|:||...
  Rat   163 TAIFIVWGVLVHLVIPPFVFMVT----EEWNYIE-GLYYSFITISTIGFGDFVAGVNPSANYHAL 222

  Fly   401 -KTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPG 464
             :.::.:::     ..|:..::|.|...||.|...:       |..|||||      .|:....
  Rat   223 YRYFVELWI-----YLGLAWLSLFVNWKVSMFVEVH-------KAIKKRRR------RRKESFE- 268

  Fly   465 APGGVSGCGTPGSGPHS--GPMGSGGTGPRRMNNKTKDLVSPKSVAQLFAGPLGASIVAMSPRTM 527
                        |.|||  ....:|.|..:.:|              :|      |.::....|.
  Rat   269 ------------SSPHSRKALQMAGSTASKDVN--------------IF------SFLSKKEETY 301

  Fly   528 LDLNPALAMGKPTFQ-----PRIPTPLAATPPPPVSSAGGMTASGIGTTSATGATSAPQPATPL- 586
            .||  ...:||...:     .|:|.|                ..|:|.....|..|.|....||
  Rat   302 NDL--IKQIGKKAMKTSGGGERVPGP----------------GHGLGAQGGDGLPSIPASLAPLV 348

  Fly   587 -------PSI-AVSTT----ASVGKDLGISTTTTTAQE 612
                   ||: .||.|    ..|.:.||......|.:|
  Rat   349 VYSKNRVPSLEEVSQTLRNKGHVSRPLGEDAAAQTPKE 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	35/207 (17%)
		Ion_trans_2	355..429	CDD:285168	12/85 (14%)
Kcnk5	NP_001034605.1	Ion_trans_2	<81..137	CDD:285168	12/98 (12%)
Kcnk5	NP_001034605.1	Ion_trans_2	171..243	CDD:285168	11/81 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000