DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and twk-43

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_872137.2	Gene:	twk-43 / 3565024	WormBaseID:	WBGene00006693	Length:	597	Species:	Caenorhabditis elegans

Alignment Length:	356	Identity:	66/356 - (18%)
Similarity:	131/356 - (36%)	Gaps:	114/356 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 TYTQHRDTQETLAVLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSS 185
            ::...|::|:.:.:   :.||..|....:..||.   ....||..|   ::...: :|.:..|:|
Worm    72 SFRLRRNSQDDMPI---IPLDRSKECVLQALRKM---SQISKGNCS---QLHNNV-NLLENCYAS 126

  Fly   186 NAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIE 250
            :..|                  |||..|               .|.|....:.|:...:..|.|.
Worm   127 DLQK------------------LKTIYD---------------SSEGSKAPEQQSAVALKKFVIV 158

  Fly   251 CVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDY--IATLSFY--IDLVLQ-------------- 297
            .....|.|.:.::          |..:.:..|.|  :|..||:  :.:::.
Worm   159 DGFEQWTTTDAIL----------FCFTVITTIGYGNVAPQSFWGRVFVIIYGTIGIPTAMMAIAN 213

  Fly   298 --RFASHLENADILEFFSIIRIMRLFKLTRHSSGLKI-----LIQTFRASAKEL----------- 344
              :|.:.|..:....|..:.|.|:.....:..:|.:|     |:::.:..||::
Worm   214 VGKFLATLLKSWTRPFLLLCRKMKKRMQKKDQNGNEIKETQRLMESSKKKAKKIEDDISSHEDEE 278

  Fly   345 ------------TLLVFFLVLGIVIFASLV--YYAERIQPNPHNDFNSIPLGLWWALVTMTTVGY 395
                        |:::|...|..:|..||:  ||.|.:         :..|.:::..||:||:|.
Worm   279 AEEEVEESDVTETIVLFVAFLVYIIAGSLLMSYYEEGM---------TFGLAIYFNFVTLTTIGL 334

  Fly   396 GDMAPKTYIGMFVGAL-CALA-GVLTIALPV 424
            ||:.|::...:||..: ||:. .:.|||:.:
Worm   335 GDLVPQSTDWLFVTLVYCAIGLALTTIAIEI 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	0/3 (0%)
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	45/233 (19%)
		Ion_trans_2	355..429	CDD:285168	22/74 (30%)
twk-43	NP_872137.2	Ion_trans_2	<162..218	CDD:285168	8/65 (12%)
twk-43	NP_872137.2	Ion_trans_2	298..372	CDD:285168	23/77 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000