DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and kcnd3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_005167059.1	Gene:	kcnd3 / 327415	ZFINID:	ZDB-GENE-030131-5626	Length:	650	Species:	Danio rerio

Alignment Length:	454	Identity:	162/454 - (35%)
Similarity:	248/454 - (54%)	Gaps:	52/454 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYY 84
            |...:..::|||.|.|.:|::.||.:.|.|.|.. :|....::....||||||.|.||..:||:|
Zfish    35 NKRQDELIILNVSGRRFQTWRNTLDRYPDTLLGS-SEKEFFFNEETREYFFDRDPDVFRSILNFY 98

  Fly    85 RTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEE 149
            ||||||||...|...::|||.|:|:....:..||:..| :.|..:.|..::|  ||:..|.|:
Zfish    99 RTGKLHYPRYECISAYDEELAFFGIIPEIISDCCYEEY-KDRKRENTERLMD--DLEDNKDSK-- 158

  Fly   150 LARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDM 214
             .....|.|               .:|..|:.|::|..|.....|:.|||.:|:::..::|.|..
Zfish   159 -LPNMTFRE---------------TMWRAFENPHTSTMALVFYYVTGFFIALSVITNVVETVPCG 207

  Fly   215 RVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSV 279
            .:|..|::.           ..:..|.   |||.::..|...||.|.|:|..::|:::.|::|.:
Zfish   208 YMPNQRDVP-----------CGERYTE---AFFCMDTACVMIFTVEYLMRLFAAPSRYRFMRSVM 258

  Fly   280 NIIDYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASA 341
            :|||.:|.|.:||.||:      ..|.|:...|   .:.|:.|:||.:|||.||:||..|.::.|
Zfish   259 SIIDVVAILPYYIGLVM------TNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCA 317

  Fly   342 KELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGM 406
            .||..|:|.|.:.|:|||::::|||:  .:..:.|.|||...|:.:|||||:|||||.|||..|.
Zfish   318 SELGFLLFSLTMAIIIFATVMFYAEK--GSSSSKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGK 380

  Fly   407 FVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVS 470
            ..|::|:|:|||.||||||||||||:..| |...||    .:|:...|::.|..|:..:..|.|
Zfish   381 IFGSICSLSGVLVIALPVPVIVSNFSRIY-HQNQRA----DKRKAQKVQKARLARMRISKSGSS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	41/97 (42%)
		BTB_2	27..117	CDD:280393	38/89 (43%)
		Ion_trans	244..439	CDD:278921	88/197 (45%)
		Ion_trans_2	355..429	CDD:285168	40/73 (55%)
kcnd3	XP_005167059.1	Shal-type	3..28	CDD:288455
		BTB	42..139	CDD:197585	41/98 (42%)
		BTB_2	42..131	CDD:280393	38/89 (43%)
		Ion_trans	213..411	CDD:278921	89/220 (40%)
		Ion_trans_2	327..407	CDD:285168	45/81 (56%)
		DUF3399	443..556	CDD:288712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910