DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and Kcng2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001100842.1	Gene:	Kcng2 / 307234	RGDID:	1309521	Length:	480	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	157/492 - (31%)
Similarity:	224/492 - (45%)	Gaps:	95/492 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRL------TEALA---NYDPILNEYFFDRHPGVFAQVLN 82
            |::||||.|.....|.|.:.|..||.||      .|.|.   :||...:|:||||.|..|..::.
  Rat    33 VIINVGGCRVRLAWAALARCPLARLERLRACRGHDELLRVCDDYDVSRDEFFFDRSPCAFRAIVA 97

  Fly    83 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSE 147
            ..|.|||......|...|.:||.:||:|..::|.||                |.||     :..|
  Rat    98 LLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCC----------------LRRL-----RRRE 141

  Fly   148 EELA----------------RKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSV 196
            ||.|                |..|      .|.:   :..:.|:..:.:.|:|..|.|....|||
  Rat   142 EEAAEARATPPARGPQTSPGRALG------SGRL---ERGRRRLRDVVENPHSGLAGKLFAYVSV 197

  Fly   197 FFICISILSFCLKTHPDMRVPIVR-NITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFE 260
            .|:.::.:..||.|.||:|....| ..:.|..|                 .|.:|.||.|||:||
  Rat   198 AFVAVTAVGLCLSTMPDVRAEEERGECSTKCRN-----------------LFVLETVCVAWFSFE 245

  Fly   261 ILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFA-----SHLENAD-ILEFFSIIRIMR 319
            .|:|.:.:.:|..|:::.:.|||.:|.|.||:.|:....|     ..||.|. :|.....:|::.
  Rat   246 FLLRSLQAESKCAFLRTPLAIIDILAILPFYVSLLAGLAAGPTGSKMLERAGLVLRLLRALRVLY 310

  Fly   320 LFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLW 384
            :.:|.|||.||:.|..|.|..|:|..||:.||.:.:.:||.||:.||| :...|.||:|:|...|
  Rat   311 VMRLARHSLGLRSLGLTVRRCAREFGLLLLFLCVAMALFAPLVHLAER-ELGAHRDFSSVPASYW 374

  Fly   385 WALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYS---HTQARAKLPK 446
            ||:::|||||||||.|::..|..|.....|:|:|.:|.||..|...|:..||   ..|.||..|:
  Rat   375 WAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQRAASPE 439

  Fly   447 -----------KRRRVLPVEQPRQ-PRLPGAPGGVSG 471
                       ..|.....|...| |...||.|.:.|
  Rat   440 PVLREDSTRDDSTRSASATEDSSQDPETAGAAGSLPG 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	38/106 (36%)
		BTB_2	27..117	CDD:280393	36/98 (37%)
		Ion_trans	244..439	CDD:278921	79/203 (39%)
		Ion_trans_2	355..429	CDD:285168	34/73 (47%)
Kcng2	NP_001100842.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		BTB_POZ_Kv6_KCNG	33..127	CDD:349691	35/93 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..167		3/28 (11%)
		Ion_trans	190..429	CDD:395416	93/256 (36%)
		Selectivity filter. /evidence=ECO:0000250	382..387		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..480		12/48 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920