DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and Kcnf1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001162575.1	Gene:	Kcnf1 / 298908	RGDID:	631414	Length:	505	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	156/479 - (32%)
Similarity:	230/479 - (48%)	Gaps:	64/479 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALA-----------NYDPILNEYFFDRHPGVFAQV 80
            :|:||||:|...|...|.:.|.|||:.|...||           :|||...|::|||.|..|..|
  Rat    37 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCV 101

  Fly    81 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLA-----VLDRLDL 140
            :..|..|::|....:|...|:.|::||.:|...::.||....::.|:..|.:|     :||.|.:
  Rat   102 IEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGV 166

  Fly   141 DTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILS 205
            |..:                     ..|:..:..:|...::|.||..|:.:.|:|...|.:|.:.
  Rat   167 DAAE---------------------GRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVV 210

  Fly   206 FCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPN 270
            .|:.|.|:::|.......|:                 |.....:|..|..|||.|.|:|..||||
  Rat   211 MCMGTIPELQVVDSEGNRVE-----------------HPTLENVETACIGWFTLEYLLRLFSSPN 258

  Fly   271 KWEFIKSSVNIIDYIATLSFYIDLVLQRFAS---HLENA-DILEFFSIIRIMRLFKLTRHSSGLK 331
            |..|..|.:||:|.:|.|.||:.|.|....:   .|.|. ..::...|:||.|:|||.||||||:
  Rat   259 KLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQ 323

  Fly   332 ILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYG 396
            .|....:.|.|||.||:.:|.:||.:|::|.|..|  |.:|...|.|||...|||::||||||||
  Rat   324 TLTYALKRSFKELGLLLMYLAVGIFVFSALGYTME--QSHPETLFKSIPQSFWWAIITMTTVGYG 386

  Fly   397 DMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPR 461
            |:.|||.:|....|:..|.||:.||||:..|::||..||:..:......|....::.:.......
  Rat   387 DIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSAES 451

  Fly   462 LPGAPGGVSGCGT--PGSGPHSGP 483
            .||  |..|...|  |......||
  Rat   452 KPG--GSRSDLDTLPPEPAAREGP 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	36/108 (33%)
		BTB_2	27..117	CDD:280393	34/100 (34%)
		Ion_trans	244..439	CDD:278921	88/198 (44%)
		Ion_trans_2	355..429	CDD:285168	36/73 (49%)
Kcnf1	NP_001162575.1	BTB	37..147	CDD:197585	36/109 (33%)
		BTB	37..138	CDD:295341	34/100 (34%)
		Ion_trans	234..429	CDD:278921	88/196 (45%)
		Ion_trans_2	343..412	CDD:285168	34/70 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820