DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and Kcnq3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_113785.4	Gene:	Kcnq3 / 29682	RGDID:	69222	Length:	873	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	92/386 - (23%)
Similarity:	150/386 - (38%)	Gaps:	68/386 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL 138
            ||...||.....||     .|..|.|.   ||..|.:..|            |.|.:.:.:|.:.
  Rat    48 PGDVEQVTLALGTG-----ADKDGTLL---LEGGGREEGQ------------RRTPQGIGLLAKT 92

  Fly   139 DLDTEKPSEEELARKFGFEEDYYK--GTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICI 201
            .|  .:|.:...|:        |:  .|:.:....:||.|:|.   |.:         .||.|.:
  Rat    93 PL--SRPVKRNNAK--------YRRIQTLIYDALERPRGWALL---YHA---------LVFLIVL 135

  Fly   202 SILSFCLKTHPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFI 266
            ..|...:.|            |.|.....:|.:|...:|.| |..|..|.....| ......|:.
  Rat   136 GCLILAVLT------------TFKEYETVSGDWLLLLETFA-IFIFGAEFALRIW-AAGCCCRYK 186

  Fly   267 SSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLK 331
            ....:.:|.:..:.::|....::....:.:....:.|  |..|.....::|:|:.::.|.....|
  Rat   187 GWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVL--ATSLRSLRFLQILRMLRMDRRGGTWK 249

  Fly   332 ILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQP-------NPHNDFNSIPLGLWWALVT 389
            :|.....|.:|||....:...|.:::.:.|||..|:..|       ....:|.:....|||.|:|
  Rat   250 LLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLIT 314

  Fly   390 MTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRR 450
            :.|:||||..|||:.|..:.|..:|.||...|||..::.|..|:.... |.|.|..:|||:
  Rat   315 LATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQE-QHRQKHFEKRRK 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	13/50 (26%)
		BTB_2	27..117	CDD:280393	13/42 (31%)
		Ion_trans	244..439	CDD:278921	49/201 (24%)
		Ion_trans_2	355..429	CDD:285168	27/80 (34%)
Kcnq3	NP_113785.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Ion_trans	122..364	CDD:395416	63/270 (23%)
		Selectivity filter. /evidence=ECO:0000250	317..322		3/4 (75%)
		Mediates interaction with calmodulin. /evidence=ECO:0000250\|UniProtKB:O43525	357..538		7/19 (37%)
		KCNQ_channel	447..651	CDD:397540
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..873
		KCNQC3-Ank-G_bd	771..867	CDD:403240
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910