Protein Alignment Shaw and Kcng1

DIOPT Version :10

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001100015.1
• Gene: Kcng1 / 296395
• RGDID: 631416
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 479
• Identity: 148/479 - (30%)
• Similarity: 236/479 - (49%)
• Gaps: 92/479 - (19%)

  Fly    13 HAAMNLINMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPIL----------NE 67
            |.:::|  .|...::::|||||::.....||.:.|.|||.:| :|..|:|.||          ||
  Rat    53 HQSISL--GDRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQL-KACTNFDDILSVCDDYDVTCNE 114

  Fly    68 YFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQ-------- 124
            :||||:||.|..:|.:.|.|||....::|...|:|||.:||:..:.::.||...|.|
  Rat   115 FFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEM 179

  Fly   125 -HRDTQETLAVLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAA 188
             .|:.:|  ..||..|.::|.||..|             |.:|   ....|:..:.::|:|....
  Rat   180 MEREDEE--EALDSEDQESEGPSTSE-------------GRLS---RCMRRLRDMVEKPHSGLPG 226

  Fly   189 KTIGVVSVFFICISILSFCLKTHPDMR--------VPIVRNITVKTANGSNGWFLDKTQTNAHIA 245
            |....:||.|:.::.::..:.|.|.:|        ..:..|:
  Rat   227 KVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGQCSQMCHNV----------------------- 268

  Fly   246 FFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFA---------- 300
             |.:|.||..||:.|.|:|||.:|:|:.|::|.:.:||.:|.|.:|:.|::...|
  Rat   269 -FIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGN 332

  Fly   301 SHLENAD-ILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYY 364
            |:|:... :|.....:||:.:.:|.|||.||:.|..|.|...:|..||:.||.:.|.:||.|:|.
  Rat   333 SYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYV 397

  Fly   365 AE-RIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIV 428
            .| .:..:|  :|.|||...|||::||||||||||.|::..|..|.....|:|:|.:|.||..|.
  Rat   398 IENEMADSP--EFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIF 460

  Fly   429 SNFAMYYSHTQARAKLPKKRRRVL 452
            ..|:..|      .:|.:::.|||
  Rat   461 HTFSRSY------LELKQEQERVL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB_Shaw-like	24..135	CDD:349723	44/129 (34%)
		Ion_trans	188..439	CDD:459842	85/270 (31%)
		PRK14959	<418..>585	CDD:184923	11/35 (31%)
Kcng1	NP_001100015.1	BTB_POZ_KCNG1_2	60..173	CDD:349728	43/113 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..205		9/38 (24%)
		Ion_trans	227..471	CDD:459842	85/275 (31%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	424..429		4/4 (100%)