DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcnc2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001346681.1	Gene:	Kcnc2 / 268345	MGIID:	96668	Length:	642	Species:	Mus musculus

Alignment Length:	507	Identity:	240/507 - (47%)
Similarity:	315/507 - (62%)	Gaps:	82/507 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYD----------------------P 63
            ::|..||:|||||.|||||::|||.:|.|||:.|..:....|                      |
Mouse     4 IESNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPQGDCLTAAGDKLQPLPPPLSPPPRPP 68

  Fly    64 ILN---------------------------------EYFFDRHPGVFAQVLNYYRTGKLHYPTDV 95
            .|:                                 |:||||||||||.|||||||||||.|.||
Mouse    69 PLSPVPSGCFEGGAGNCSSHGGNGGNGGSDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADV 133

  Fly    96 CGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEE--LARKFGFEE 158
            |||||||||.|||:|...|||||||||.||||.:|.|.:.:..||....|.::|  .|::.|.|:
Mouse   134 CGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIED 198

  Fly   159 -------DYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRV 216
                   |   |....|::::||:|:||::||||.||:.|...|:|||.:||.:|||:||....
Mouse   199 AAGLGGPD---GKSGRWRKLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFN- 259

  Fly   217 PIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNI 281
             ||:|.|....||::.....:.:|:.  |..|:|.||..|||||.|||.:.||||.||||:.:||
Mouse   260 -IVKNKTEPVINGTSPVLQYEIETDP--ALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNI 321

  Fly   282 IDYIATLSFYIDLVLQRFASHLENADILEFFSI---IRIMRLFKLTRHSSGLKILIQTFRASAKE 343
            ||::|.|.||:::.|...:|.... |:|.|..:   :||:|:||||||..||::|..|.|||..|
Mouse   322 IDFVAILPFYLEVGLSGLSSKAAK-DVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNE 385

  Fly   344 LTLLVFFLVLGIVIFASLVYYAERI--QPN-----PHNDFNSIPLGLWWALVTMTTVGYGDMAPK 401
            ..||:.||.||::|||:::|||||:  |||     .|..|.:||:|.|||:|||||:|||||.|:
Mouse   386 FLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQ 450

  Fly   402 TYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLP 453
            |:.||.||||||||||||||:||||||:||.||||...|:.|||:||::.:|
Mouse   451 TWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	69/152 (45%)
		BTB_2	27..117	CDD:280393	62/144 (43%)
		Ion_trans	244..439	CDD:278921	116/204 (57%)
		Ion_trans_2	355..429	CDD:285168	52/80 (65%)
Kcnc2	NP_001346681.1	BTB_KCNC2_4	7..170	CDD:349722	75/162 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..98		3/52 (6%)
		Ion_trans	232..488	CDD:395416	136/260 (52%)
		Selectivity filter. /evidence=ECO:0000250	441..446		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2047
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71199
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1553
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48788
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	1	1.000	-	-		otm42984
orthoMCL	1	0.900	-	-		OOG6_102927
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3268
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870