DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and Kcna2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_037102.1	Gene:	Kcna2 / 25468	RGDID:	2950	Length:	499	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	177/469 - (37%)
Similarity:	256/469 - (54%)	Gaps:	88/469 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKL 89
            |||:|:.|:|.||...||.:.|.|.|....:.:..:||:.|||||||:...|..:|.||:: |:|
  Rat    34 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 98

  Fly    90 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKF 154
            ..|.:|...:|.||:.|:.|.                                     ||....|
  Rat    99 RRPVNVPLDIFSEEIRFYELG-------------------------------------EEAMEMF 126

  Fly   155 GFEEDYYKGTISWWQEMKP--------RIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTH 211
            ..:|.|.|      :|.:|        ::|.||:.|.||..|:.|.:|||..|.|||:||||:|
  Rat   127 REDEGYIK------EEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLET- 184

  Fly   212 PDMRVPIVRN---------ITVKT-ANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFI 266
                :||.|:         :|..| :|.:.|:   :..|:....||.:|.:|..||:||.||||.
  Rat   185 ----LPIFRDENEDMHGGGVTFHTYSNSTIGY---QQSTSFTDPFFIVETLCIIWFSFEFLVRFF 242

  Fly   267 SSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENAD---------ILEFFSIIRIMRLFK 322
            :.|:|..|..:.:||||.:|.:.::|.|..: .|...|:|.         ||....::|:.|:||
  Rat   243 ACPSKAGFFTNIMNIIDIVAIIPYFITLGTE-LAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFK 306

  Fly   323 LTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWAL 387
            |:|||.||:||.||.:||.:||.||:|||.:|:::|:|.||:||..:.:  :.|.|||...|||:
  Rat   307 LSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERD--SQFPSIPDAFWWAV 369

  Fly   388 VTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVL 452
            |:|||||||||.|.|..|..||:|||:|||||||||||||||||..:| |.:...   :::.:.|
  Rat   370 VSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HRETEG---EEQAQYL 430

  Fly   453 PVEQPRQPRLPGAP 466
            .|..  .|::|.:|
  Rat   431 QVTS--CPKIPSSP 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	34/98 (35%)
		BTB_2	27..117	CDD:280393	34/90 (38%)
		Ion_trans	244..439	CDD:278921	101/203 (50%)
		Ion_trans_2	355..429	CDD:285168	44/73 (60%)
Kcna2	NP_037102.1	Tetramerization domain. /evidence=ECO:0000305\|PubMed:11007484	1..125		37/127 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:365784	47/167 (28%)
		Ion_trans	162..420	CDD:395416	123/269 (46%)
		S4-S5 linker. /evidence=ECO:0000305\|PubMed:16002579	312..325		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000305	374..379		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000269\|PubMed:7477295	497..499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810