DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and Kcna1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_775118.1	Gene:	Kcna1 / 24520	RGDID:	2949	Length:	495	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	171/474 - (36%)
Similarity:	253/474 - (53%)	Gaps:	86/474 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PKKMQHYAHAAMNLINMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYF 69
            |::..|..|...        .|||:|:.|:|.||...||.:.|.|.|....:.:..:||:.||||
  Rat    25 PRQADHDDHECC--------ERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYF 81

  Fly    70 FDRHPGVFAQVLNYYRT-GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLA 133
            |||:...|..:|.||:: |:|..|.:|...:|.||::|:.|.
  Rat    82 FDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELG----------------------- 123

  Fly   134 VLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKP--------RIWSLFDEPYSSNAAKT 190
                          ||...||..:|.:.|      :|.:|        ::|.||:.|.||..|:.
  Rat   124 --------------EEAMEKFREDEGFIK------EEERPLPEKEYQRQVWLLFEYPESSGPARV 168

  Fly   191 IGVVSVFFICISILSFCLKTHPDMR-----VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIE 250
            |.:|||..|.|||:.|||:|.|:::     ...:..|...|...::..|.|        .||.:|
  Rat   169 IAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFTD--------PFFIVE 225

  Fly   251 CVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQ-------RFASHLENADI 308
            .:|..||:||::|||.:.|:|.:|.|:.:|.||.:|.:.::|.|..:       :......:..|
  Rat   226 TLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAI 290

  Fly   309 LEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPH 373
            |....::|:.|:|||:|||.||:||.||.:||.:||.||:|||.:|:::|:|.||:||..:...|
  Rat   291 LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESH 355

  Fly   374 NDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHT 438
              |:|||...|||:|:|||||||||.|.|..|..||:|||:|||||||||||||||||..:| |.
  Rat   356 --FSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HR 417

  Fly   439 QARAKLPKKRRRVLPVEQP 457
            :...   :::.::|.|..|
  Rat   418 ETEG---EEQAQLLHVSSP 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	34/98 (35%)
		BTB_2	27..117	CDD:280393	34/90 (38%)
		Ion_trans	244..439	CDD:278921	98/201 (49%)
		Ion_trans_2	355..429	CDD:285168	45/73 (62%)
Kcna1	NP_775118.1	Tetramerization domain. /evidence=ECO:0000305	1..128		40/147 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		1/4 (25%)
		BTB_POZ	37..163	CDD:365784	47/168 (28%)
		Ion_trans	166..418	CDD:395416	116/262 (44%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	310..323		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000305	493..495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810