DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcna10

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001074609.1	Gene:	Kcna10 / 242151	MGIID:	3037820	Length:	511	Species:	Mus musculus

Alignment Length:	457	Identity:	175/457 - (38%)
Similarity:	258/457 - (56%)	Gaps:	75/457 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT 86
            :...||::|:.|:|.||...||.:.|.|.|....:.:..:|.:.|||||||:...|..:|.||::
Mouse    83 EGNQRVIINIAGLRFETQLRTLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQS 147

  Fly    87 -GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEEL 150
             ||:..|.:|...:|.:|:.|:.|.|..::        |.|:.:..:.     |.:|..|:
Mouse   148 GGKIRRPANVPIDVFADEISFYELGSEAMD--------QFREDEGFIK-----DPETLLPT---- 195

  Fly   151 ARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMR 215
                   .|:::           :.|.||:.|.||:||:.:.||||..:.|||..|||:|.|:.|
Mouse   196 -------NDFHR-----------QFWLLFEYPESSSAARGVAVVSVLVVVISITIFCLETLPEFR 242

  Fly   216 ----VPIVRNITVKTANGSNGWFLDKT---QTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWE 273
                :.:||:.::.|         :||   ||.....||.:|..|..|||||:::||:..|:|.:
Mouse   243 EDRELKVVRDPSINT---------NKTGLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTD 298

  Fly   274 FIKSSVNIIDYIATLSFY----IDLVLQRFASHLENAD--ILEFFSIIRIMRLFKLTRHSSGLKI 332
            |.|:.:||||.|:.:.::    .:||.:...|..:|..  ||....::|:.|:|||:|||.||:|
Mouse   299 FFKNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQI 363

  Fly   333 LIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGD 397
            |.||.:||.:||.||:|||.:|:::|:|.||:||..:|..|  |:|||.|.|||:||||||||||
Mouse   364 LGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESH--FSSIPDGFWWAVVTMTTVGYGD 426

  Fly   398 MAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRL 462
            |.|.|..|..||.|||:|||||||||||||||||..:| |.:              .|...:|.:
Mouse   427 MCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFY-HRE--------------TENEEKPNI 476

  Fly   463 PG 464
            ||
Mouse   477 PG 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	32/98 (33%)
		BTB_2	27..117	CDD:280393	32/90 (36%)
		Ion_trans	244..439	CDD:278921	104/200 (52%)
		Ion_trans_2	355..429	CDD:285168	48/73 (66%)
Kcna10	NP_001074609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..44
		BTB_2	88..179	CDD:280393	32/98 (33%)
		BTB	88..171	CDD:197585	30/82 (37%)
		Ion_trans	267..467	CDD:278921	104/202 (51%)
		Ion_trans_2	382..458	CDD:285168	50/77 (65%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810