DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and Kcng1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001074603.1	Gene:	Kcng1 / 241794	MGIID:	3616086	Length:	514	Species:	Mus musculus

Alignment Length:	527	Identity:	151/527 - (28%)
Similarity:	241/527 - (45%)	Gaps:	124/527 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTYIPKKMQHYAHAAMNLIN--------------------------------------MDSENRV 27
            ||.:|....||.::|::..:                                      .|...::
Mouse     1 MTLLPGDNSHYDYSALSCASDTSFHPAFFPQRQAIKGVFYRRAQRLRPQDDLHQSCSLGDRRRQI 65

  Fly    28 VLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPIL----------NEYFFDRHPGVFAQVLN 82
            ::|||||::.....||.:.|.|||.:| :|..|:|.||          ||:||||:||.|..:|.
Mouse    66 IINVGGIKYSLPWTTLDEFPLTRLGQL-KACTNFDDILSVCDDYDVTCNEFFFDRNPGAFGTILT 129

  Fly    83 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQH-------RDTQETLAVLDRLDL 140
            :.|.|||....::|...|:|||.:||:..:.::.||...|.|.       .:.:|....||..|.
Mouse   130 FLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREEEEEPLDSEDQ 194

  Fly   141 DTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILS 205
            ::|.||..|             |.:|   ....|:..:.:.|:|....|....:||.|:.::.::
Mouse   195 ESEGPSASE-------------GRLS---RCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVN 243

  Fly   206 FCLKTHPDMR--------VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEIL 262
            ..:.|.|.:|        ..:..|:                        |.:|.||..||:.|.|
Mouse   244 LSVSTLPSLREEEEQGQCSQMCHNV------------------------FIVESVCVGWFSLEFL 284

  Fly   263 VRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFA----------SHLENAD-ILEFFSIIR 316
            :|||.:|:|:.|::|.:.:||.:|.|.:|:.|::...|          |:|:... :|.....:|
Mouse   285 LRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAASSRRKPSTGNSYLDKVGLVLRVLRALR 349

  Fly   317 IMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAE-RIQPNPHNDFNSIP 380
            |:.:.:|.|||.||:.|..|.|...:|..||:.||.:.|.:||.|:|..| .:..:|  :|.|||
Mouse   350 ILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSP--EFTSIP 412

  Fly   381 LGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLP 445
            ...|||::||||||||||.|::..|..|.....|:|:|.:|.||..|...|:..|      .:|.
Mouse   413 ACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSY------LELK 471

  Fly   446 KKRRRVL 452
            :::.|||
Mouse   472 QEQERVL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	41/107 (38%)
		BTB_2	27..117	CDD:280393	38/99 (38%)
		Ion_trans	244..439	CDD:278921	77/206 (37%)
		Ion_trans_2	355..429	CDD:285168	34/74 (46%)
Kcng1	NP_001074603.1	BTB_POZ_KCNG1_2	60..173	CDD:349728	43/113 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..205		8/37 (22%)
		Ion_trans	227..471	CDD:395416	85/275 (31%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	424..429		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810