DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcnv2

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_899002.1	Gene:	Kcnv2 / 240595	MGIID:	2670981	Length:	562	Species:	Mus musculus

Alignment Length:	452	Identity:	139/452 - (30%)
Similarity:	219/452 - (48%)	Gaps:	58/452 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LNVGGIRHETYKATLKKIPATRLSRLTEALA---------NYDPILNEYFFDRHPGVFAQVLNYY 84
            :||||..:......|...|.|||.||..:..         :|:...:||||||.|.||..:.|:|
Mouse   109 VNVGGHSYLLECCELANYPKTRLGRLATSTTRRGQLGLCDDYEAQTDEYFFDRDPAVFQLIYNFY 173

  Fly    85 RTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRD-TQETLAVLDRLDLDTEKPSEE 148
            .:|.|....::|...|.|||.:||:.......||.:.:.:.|| ..|.|.:...|....:....|
Mouse   174 TSGVLLVRDELCPRSFLEELGYWGVRLKYTPRCCRICFEERRDELSEQLKIQRELRAQAQAEEAE 238

  Fly   149 ELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPD 213
            ||.|...|           :...:.|:|:|.::|:||.|||.:||.:..|:.||:::..|.|..:
Mouse   239 ELFRDMRF-----------YGPQRQRLWNLMEKPFSSVAAKAMGVATNLFVLISVVALALNTVEE 292

  Fly   214 MRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSS 278
            |:    ......|..|.....|:           ::|.:|.|:||.|.|:|..|:||...|.:|:
Mouse   293 MQ----HQAEQGTGGGDPRPILE-----------HVEMLCVAFFTLEFLLRLASTPNLQRFARSA 342

  Fly   279 VNIIDYIATLSFYIDLVLQRFASH-------------LEN-------ADILEFFSIIRIMRLFKL 323
            :|::|.:|.|.||:.|:|:.|.|.             ||.       ..:|....::||.|:.||
Mouse   343 LNLVDLVAILPFYLQLLLECFTSEDQRHNKDSPREHDLETVGRVGKVGQVLRIMRLMRIFRILKL 407

  Fly   324 TRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALV 388
            .|||:||:....|.|...:::..|:.|:.:||..|::.||..|...|.  .:|.||....|||.|
Mouse   408 ARHSTGLRAFGFTLRQCYQQVGCLMLFITMGIFSFSAAVYSVEHDVPG--TNFTSILHAWWWAAV 470

  Fly   389 TMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRR 450
            :::|||||||.|:|::|.....||...|::...:|:.::.:.|:.|||..:|......:|.|
Mouse   471 SISTVGYGDMYPETHLGRLFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTAIRRER 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	34/104 (33%)
		BTB_2	27..117	CDD:280393	32/96 (33%)
		Ion_trans	244..439	CDD:278921	72/214 (34%)
		Ion_trans_2	355..429	CDD:285168	27/73 (37%)
Kcnv2	NP_899002.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		BTB	107..198	CDD:197585	31/88 (35%)
		BTB	107..198	CDD:295341	31/88 (35%)
		Ion_trans	305..521	CDD:278921	73/228 (32%)
		Ion_trans_2	434..509	CDD:285168	29/76 (38%)
		Selectivity filter. /evidence=ECO:0000250	474..479		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820