DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcng3

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_705732.1	Gene:	Kcng3 / 225030	MGIID:	2663923	Length:	433	Species:	Mus musculus

Alignment Length:	440	Identity:	147/440 - (33%)
Similarity:	222/440 - (50%)	Gaps:	54/440 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVFAQVLN 82
            |||||||.|:...:..||..|..|:|||         .|...:||...||||||||...|..:|.
Mouse    11 VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILL 75

  Fly    83 YYR-TGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPS 146
            |.| .|||.:...:|...|..|:.:|||:...:|.||............|....|.|..:..:|:
Mouse    76 YVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTHTFHAADELGREQPRPA 140

  Fly   147 EEELA--RKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLK 209
            ..|.|  |:             |.:.|:    ..|:||.||.||:.:..|||.|:.:|::..|..
Mouse   141 GPEAAPSRR-------------WLERMR----RTFEEPTSSLAAQILASVSVVFVIVSMVVLCAS 188

  Fly   210 THPDMRVPIVRNITVKTANGSNGWFLDKTQTNA---HIAFFYIECVCNAWFTFEILVRFISSPNK 271
            |.||.|..:..|.::.          |:::.:|   ......||.:|..|||.|.:||||.|.||
Mouse   189 TLPDWRAAVADNRSLD----------DRSRYSASPGREPSGIIEAICIGWFTAECIVRFIVSKNK 243

  Fly   272 WEFIKSSVNIIDYIATLSFYIDLVLQRFA---SHLENADILEFFSIIRIMRLF---KLTRHSSGL 330
            .||:|..:||||.:|...:||.:::..|.   |.|:.|.:.  ..::|:||:|   ||.||..||
Mouse   244 CEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVT--LRVLRMMRIFWVIKLARHFIGL 306

  Fly   331 KILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAER---IQPNPHNDFNSIPLGLWWALVTMTT 392
            :.|..|.:...:|:.:|:.|:.:.:.||::|....|.   ::.: :.||.|||...||.:::|||
Mouse   307 QTLGLTLKRCYREMAMLLVFICVAMAIFSALSQLLEHGLDLETS-NKDFASIPAACWWVIISMTT 370

  Fly   393 VGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARA 442
            ||||||.|.|..|..:|.:|.::|::.:|||:..|..:|...|...:.|:
Mouse   371 VGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRS 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	42/107 (39%)
		BTB_2	27..117	CDD:280393	40/99 (40%)
		Ion_trans	244..439	CDD:278921	75/203 (37%)
		Ion_trans_2	355..429	CDD:285168	30/76 (39%)
Kcng3	NP_705732.1	BTB	11..119	CDD:197585	42/107 (39%)
		BTB	11..111	CDD:295341	40/99 (40%)
		Ion_trans	216..417	CDD:278921	75/203 (37%)
		Ion_trans_2	<360..405	CDD:285168	20/44 (45%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820