DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and twk-45

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001122742.2	Gene:	twk-45 / 190614	WormBaseID:	WBGene00006695	Length:	508	Species:	Caenorhabditis elegans

Alignment Length:	401	Identity:	75/401 - (18%)
Similarity:	142/401 - (35%)	Gaps:	136/401 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LDLDTEKPSEEELAR---KFGFEEDYYKGTISWWQEMKPRI----------WSLFDEPYSSNAAK 189
            |.:||.....|:::.   .|.|:|..||       |.|.:|          |..:  .:.....:
Worm    30 LKIDTHMGKVEDMSPFGFHFEFDEKKYK-------ERKKQIRREKITWFFAWLAY--YHHKFGIR 85

  Fly   190 TIGVVSVF--FIC--------------ISILSFCLKTHPDMRVPIVRNITVK------TANGSNG 232
            .|.::|:.  :||              |..|...||:..:    |::|.|:.      |.||.
Worm    86 HITLISILAAYICLGGFLFQKLESPREIEELQETLKSMNE----IIKNETMDIIKITLTTNGE-- 144

  Fly   233 WFLDKTQTNAHIAFFYIECVC--------NAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLS 289
               |:.|....:...|...:.        :||...|.|               .:|::.|.::.:
Worm   145 ---DRNQKLGDLLRAYHRILLETEGKFHGSAWHKSENL---------------DMNLMWYFSSAT 191

  Fly   290 FY----------------------IDLVLQRFAS------HLENADILEFFSIIRIMR---LFKL 323
            ||                      :.:|   :||      .|...||..:|.  ::|.   :|.:
Worm   192 FYSMTLFSTIGYGTITCQTFWGKTVSMV---YASIGLPIMLLVLGDIGVWFQ--KVMTNAYIFVM 251

  Fly   324 TRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFA-------SLVYYAERIQPNPHNDFNSIPL 381
            .::.|..|   |:.....|| |||..:|.: :|:|.       :::.:.:.....|..:|..
Worm   252 LKYKSLRK---QSIEIKRKE-TLLPMWLAM-LVVFTYIIICTLTILLFDDNEGDEPGINFFD--- 308

  Fly   382 GLWWALVTMTTVGYGDMAPKTY-------IGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQ 439
            ..::..:::||:|.||:.|...       :...:|  .||..::..::...:..|.:.:.||...
Worm   309 AFYFTFISLTTIGLGDVMPYNIQYSPFLPLAFLLG--LALISIVNTSIYSTLYQSFYNLIYSLED 371

  Fly   440 ARAKLPKKRRR 450
            ...::...|||
Worm   372 QLDRIHNSRRR 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585
		BTB_2	27..117	CDD:280393
		Ion_trans	244..439	CDD:278921	43/247 (17%)
		Ion_trans_2	355..429	CDD:285168	13/87 (15%)
twk-45	NP_001122742.2	Ion_trans_2	<185..241	CDD:285168	10/60 (17%)
twk-45	NP_001122742.2	Ion_trans_2	278..354	CDD:285168	13/80 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000