Protein Alignment Shaw and egl-23

DIOPT Version :9

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001255775.1
• Gene: egl-23 / 178358
• WormBaseID: WBGene00001190
• Length: 726
• Species: Caenorhabditis elegans
• Alignment Length: 773
• Identity: 141/773 - (18%)
• Similarity: 225/773 - (29%)
• Gaps: 304/773 - (39%)

  Fly    12 AHAAMNLINMDS-ENRVV-------------LNVGGIRHETYKATLKKIPATRLSRLTEALANYD 62
            |:|....:.|.| |:|.|             :|:...:|.....||::....|......||.::
 Worm    70 AYAIFGALVMRSLESRTVTSIEKKTDVHRRHVNLTNFQHPPTPITLEQRHRRRRRHNETALEDH- 133

  Fly    63 PILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPC--CWMTYTQH 125
              |:|. ..|.....|.::   |:.|.  ...|...:...|..|..||...|:..  |:....:|
 Worm   134 --LSEK-LSREKRAAAHIM---RSRKC--VISVIKKMSSMECSFDTLDEKLVKALDECYHVAVEH 190

  Fly   126 RDTQETLAVLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWS---LFDEPYSSNA 187
             :|.....:......:.|...||.       |||     :|.|..|...:::   :....|.:.|
 Worm   191 -NTHVNHVLFTNSKEEVESVGEEA-------EED-----VSEWSFMDSLLFAFTVITTIGYGNVA 242

  Fly   188 AKTI---------GVVSVFFICISIL--------------SFCLKTHPDMRVPIVRNITVKTANG 229
            .:|.         |::.:.|..::|.              |||.||...::
 Worm   243 PRTFGGRLFVIGYGLIGIPFTLLAIADLGKFISEMMVEAKSFCRKTWKKLK-------------- 293

  Fly   230 SNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDL 294
                                    .||           :||   ||:
 Worm   294 ------------------------KAW-----------NPN---FIR------------------ 302

  Fly   295 VLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFA 359
                 |..|.|.||.|     :|:...|:.......::..:....:..|.|.| |.|.|..:.|.
 Worm   303 -----AKDLSNTDIEE-----KILDNEKIENEPETSEVSEEEDDLTETEATSL-FILFLVYIAFG 356

  Fly   360 SLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPK--TYIGMFVGALCALAGVLTIAL 422
            ..:..|.    .|..||..   .:::..||:|::|.||:.|:  ||:.:.:..:.....:.|||:
 Worm   357 GFMLAAY----EPDMDFFK---AVYFNFVTLTSIGLGDIVPRSETYMLITIVYIAIGLALTTIAI 414

  Fly   423 PVPV--------------IVSNFAMYYSHTQARAK-----------LPKKRRRVL---------- 452
            .:..              .|.|.|:::...:...|           ||....:.|
 Worm   415 EIAADALKKLHYFGRKIENVGNVAIWFGGKKITMKALVKNLGDQFNLPTTVVKNLNLDHFVDQAI 479

  Fly   453 ------------PVEQPRQPRLPGAPGGVSGC-----GTPGSGPHSGPMGSGGTGPRRMNNKTKD 500
                        |..:|...|..........|     .||...|...|:              ..
 Worm   480 KVEEGEIETLRPPPYEPPSDRFEAEFADEPECEWIRDPTPTPPPSPQPV--------------YR 530

  Fly   501 LVSPKSVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKPTFQ----------------------- 542
            |.|||.|.   ..||      .|| |:.|::.|:|...|...
 Worm   531 LPSPKPVT---PEPL------PSP-TITDVSLAIATPSPEESDDDQELILPSPEPSPVREPTPPP 585

  Fly   543 -PRIPTPLAAT-----------PPPPVSSAGGMTASGI--------------------------- 568
             ||.|||...|           ||||.:....:||:.|
 Worm   586 PPREPTPREPTPEPEPVREPTPPPPPPAKPRPLTAAEIAAQKRKAYSEEAWRRYQEYQKQWKKFR 650

  Fly   569 ---------GTTSATGATSAPQPATPLPSIAVSTTASVGKDLGISTTTTTAQETSKKA 617
                     |.:::..:||.|...:|.....|.|..|....   |.|:..:.:||:.|
 Worm   651 QTQKTPAPSGASTSGASTSKPSGTSPESGAGVCTGPSTRSQ---SITSVASGKTSRSA 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	21/112 (19%)
		BTB_2	27..117	CDD:280393	20/102 (20%)
		Ion_trans	244..439	CDD:278921	40/210 (19%)
		Ion_trans_2	355..429	CDD:285168	17/89 (19%)
egl-23	NP_001255775.1	Ion_trans_2	216..276	CDD:285168	10/64 (16%)
		Ion_trans_2	347..423	CDD:285168	19/82 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000