DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and shl-1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_500975.2	Gene:	shl-1 / 177400	WormBaseID:	WBGene00022240	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	466	Identity:	165/466 - (35%)
Similarity:	245/466 - (52%)	Gaps:	72/466 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YIPKKMQHYAHAAMNLINMD------SENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANY 61
            ::|...|....|.:.:...|      |:.::.:|:.|.|.||:|.||:|.|.|.|.. .|....|
Worm    18 WVPISRQPMPQAPVAIQAKDLAVDHVSDEKLAINISGRRFETWKNTLEKFPETLLGS-NEKEFFY 81

  Fly    62 DPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTY-TQH 125
            |....||||||.|.:|..:|.:|||||||||...|...::|||.|:|:..:.:..||:..| .:.
Worm    82 DEDTGEYFFDRDPDIFRHILTFYRTGKLHYPRHECLVAYDEELSFFGIMPDLISDCCYEDYKDKK 146

  Fly   126 RDTQETLAV--LDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAA 188
            |:.||.|..  ::..|:.|.|.|                        :|.::|:.|:.|::::.|
Worm   147 RENQERLQEERVENADISTLKLS------------------------LKEKMWAAFENPHTTSIA 187

  Fly   189 KTIGVVSVFFICISILSFCLKTHP----DMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYI 249
            .....|..|||.:|::...::|.|    |       |::|........            .||.|
Worm   188 LVFYYVIGFFIAVSVMCNIVETIPCGYED-------NVSVTCGEAYEE------------QFFVI 233

  Fly   250 ECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFF-- 312
            :..|...||.|..:|.||:|::.:|::|.:::||.||.:.:|:.|||      .:|.|:...|
Worm   234 DTACVIIFTIEYFLRLISAPDRIKFMRSIMSVIDVIAIMPYYVSLVL------TDNKDVSGLFVT 292

  Fly   313 -SIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDF 376
             .:.|:.|:||.:|||.||:||..|.::.|.||..|||.|.:.|:|||:::||||:  ......|
Worm   293 LRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATIMYYAEK--KVDATRF 355

  Fly   377 NSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQAR 441
            .|||...|:.:||:||:|||||.|.|.:|..||.:|:|:|||.||||||||||||:..| |...|
Worm   356 TSIPSAFWYTIVTLTTLGYGDMVPSTIMGKIVGGVCSLSGVLVIALPVPVIVSNFSRIY-HQNQR 419

  Fly   442 A---KLPKKRR 449
            |   |..||.|
Worm   420 ADKRKAQKKAR 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	42/98 (43%)
		BTB_2	27..117	CDD:280393	39/89 (44%)
		Ion_trans	244..439	CDD:278921	89/197 (45%)
		Ion_trans_2	355..429	CDD:285168	40/73 (55%)
shl-1	NP_500975.2	BTB_POZ	6..149	CDD:365784	48/131 (37%)
		Ion_trans	187..416	CDD:366146	99/256 (39%)
		DUF3399	460..528	CDD:371777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810