DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and Kcnd1

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_032449.1	Gene:	Kcnd1 / 16506	MGIID:	96671	Length:	651	Species:	Mus musculus

Alignment Length:	678	Identity:	211/678 - (31%)
Similarity:	303/678 - (44%)	Gaps:	168/678 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHY 91
            :|:||.|.|.||:|.||.:.|.|.|.. :|....||....||||||.|.:|..|||:||||:||.
Mouse    42 LVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDAESGEYFFDRDPDMFRHVLNFYRTGRLHC 105

  Fly    92 PTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKFGF 156
            |...|...|:|||.|:||....|..||...|.            ||...:.|:.:|:|.|.:.|.
Mouse   106 PRQECIQAFDEELAFYGLVPELVGDCCLEEYR------------DRKKENAERLAEDEEAEQAGE 158

  Fly   157 EEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRN 221
            ......|:     .::.|:|..|:.|::|.||.....|:.|||.:|:::..::|.|
Mouse   159 GPALPAGS-----SLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP--------- 209

  Fly   222 ITVKTANGSNGWFLDKTQT---NAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIID 283
                 ..|:..| ..|.|:   ....|||.::..|...||.|.|:|..::|::..|::|.:::||
Mouse   210 -----CRGTPRW-PSKEQSCGDRFPTAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLID 268

  Fly   284 YIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAKELT 345
            .:|.|.:||.|.:.:      |.|:...|   .:.|:.|:||.:|||.||:||..|.::.|.||.
Mouse   269 VVAILPYYIGLFVPK------NDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELG 327

  Fly   346 LLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGA 410
            .|:|.|.:.|:|||::::|||:  .....:|.|||...|:.:|||||:|||||.|.|..|...|:
Mouse   328 FLLFSLTMAIIIFATVMFYAEK--GTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGS 390

  Fly   411 LCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVS----- 470
            :|:|:|||.||||||||||||:..| |...||...:.:::|      |..|:..|..|.:
Mouse   391 ICSLSGVLVIALPVPVIVSNFSRIY-HQNQRADKRRAQQKV------RLARIRLAKSGTTNAFLQ 448

  Fly   471 -----GCGTPGSGP--------------------------------------------------- 479
                 |....|||.
Mouse   449 YKQNGGLEDSGSGDGQMLCVRSRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSLGGRTS 513

  Fly   480 -----HSGPMGSG----GTGPRRMNNKTKDL------VSPKSVAQL--FAG------PLGASIVA 521
                 .|.|||.|    ....||:|.:...|      ||..|:.:|  .||      |...|.:.
Mouse   514 RSTSVSSQPMGPGSLFSSCCSRRVNRRAIRLANSTASVSRGSMQELDTLAGLRRSPAPQTRSSLN 578

  Fly   522 MSPRTMLDLN-------PALAMGKPTFQPRIPTPLAATP--PPPVSSAGGMTASGIGTTSATGAT 577
            ..|...||||       .|:.        .||||.|.||  ..|.|.:||   .|.|.|
Mouse   579 AKPHDSLDLNCDSRDFVAAII--------SIPTPPANTPDESQPSSPSGG---GGSGGT------ 626

  Fly   578 SAPQPATPLPSIAVSTTASVGKDLGIST 605
                |.|.|.:.::.|...:.:.:.||:
Mouse   627 ----PNTTLRNSSLGTPCLLPETVKISS 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	46/97 (47%)
		BTB_2	27..117	CDD:280393	43/89 (48%)
		Ion_trans	244..439	CDD:278921	85/197 (43%)
		Ion_trans_2	355..429	CDD:285168	39/73 (53%)
Kcnd1	NP_032449.1	Interaction with KCNIP2. /evidence=ECO:0000250	2..20
		BTB_POZ	6..143	CDD:365784	48/113 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..164		5/19 (26%)
		Ion_trans	185..417	CDD:395416	96/255 (38%)
		Selectivity filter. /evidence=ECO:0000250	372..377		3/4 (75%)
		DUF3399	447..550	CDD:403174	13/102 (13%)
		Mediates dendritic targeting. /evidence=ECO:0000250	474..489		0/14 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	566..585		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..651		20/63 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810