Protein Alignment Shaw and Kcnc3

DIOPT Version :9

• Sequence 1: NP_001137782.1
• Gene: Shaw / 33599
• FlyBaseID: FBgn0003386
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_036008594.1
• Gene: Kcnc3 / 16504
• MGIID: 96669
• Length: 807
• Species: Mus musculus
• Alignment Length: 630
• Identity: 264/630 - (41%)
• Similarity: 343/630 - (54%)
• Gaps: 106/630 - (16%)

  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTE----ALANYDPILNEYFFDRHPGVFAQVLNYYRT 86
            ::|:||||:|||||::||:.:|.|||:.|||    |..:|||..:|:||||||||||.|||||||
Mouse    91 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRT 155

  Fly    87 GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELA 151
            ||||.|.|||||||||||.|||:|...||.||||||.||||.:|.|...:..|......:....|
Mouse   156 GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSANANANAGGA 220

  Fly   152 RKFGFEE---------DYYKGTI------------------------SWWQEMKPRIWSLFDEPY 183
            ...|.::         |...|.:                        :||:..:||:|:||::||
Mouse   221 HDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGAGGAGGTWWRRWQPRVWALFEDPY 285

  Fly   184 SSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPIVRNITVKTAN---GSNGWFLDKTQTNAHIA 245
            ||.||:.:...|:|||.|||.:|||:||...  ..:.|.||..|:   |:....:...:......
Mouse   286 SSRAARYVAFASLFFILISITTFCLETHEGF--IHISNKTVTQASPIPGAPPENITNVEVETEPF 348

  Fly   246 FFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLENADILE 310
            ..|:|.||..|||||.|:|....|:|.||:|||:||||.:|.|.||:::.|...:|.... |:|.
Mouse   349 LTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAK-DVLG 412

  Fly   311 FFSI---IRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNP 372
            |..:   :||:|:||||||..||::|..|.|||..|..||:.||.||::|||:::||||||..:|
Mouse   413 FLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADP 477

  Fly   373 -------HNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSN 430
                   |..|.:||:|.|||:|||||:|||||.|||:.||.||||||||||||||:||||||:|
Mouse   478 DDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNN 542

  Fly   431 FAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPHSGPMGSGGTGPRRMN 495
            |.||||...|:.|||||:.:.:|     :|..||:|........|...||. ..||||..|
Mouse   543 FGMYYSLAMAKQKLPKKKNKHIP-----RPPQPGSPNYCKPDPPPPPPPHP-HHGSGGISP---- 597

  Fly   496 NKTKDLVSPKSVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKPTFQPRIPTPLAATPPPPVSSA 560
               ...::|.|:....||                                     |.||.| .:.
Mouse   598 ---PPPITPPSMGVNVAG-------------------------------------AYPPGP-HTH 621

  Fly   561 GGMTASGIGTTSATGATSAPQPATPLP--SIAVSTTASVGKDLGI 603
            .|:...|.|.....|....|.|..|.|  ...|..|...|.|||:
Mouse   622 PGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIETNRAGSDLGV 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	69/101 (68%)
		BTB_2	27..117	CDD:280393	63/93 (68%)
		Ion_trans	244..439	CDD:278921	113/204 (55%)
		Ion_trans_2	355..429	CDD:285168	52/80 (65%)
Kcnc3	XP_036008594.1	BTB_KCNC1_3	91..204	CDD:349721	75/112 (67%)
		Ion_trans	290..551	CDD:395416	131/263 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2047
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1553
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42984
orthoMCL	1	0.900	-	-		OOG6_102927
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830