DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and Kcna7

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_034726.2	Gene:	Kcna7 / 16495	MGIID:	96664	Length:	489	Species:	Mus musculus

Alignment Length:	441	Identity:	176/441 - (39%)
Similarity:	237/441 - (53%)	Gaps:	83/441 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTG--- 87
            |:||||.|:|.||...||.:.|.|.|.........||....|||||||...|..||.||::|
Mouse    46 RLVLNVAGLRFETRARTLGRFPDTLLGDPVRRSRFYDGARREYFFDRHRPSFDAVLYYYQSGGRL 110

  Fly    88 --KLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRL--DLDTEKPSEE 148
              ..|.|.||    |.||:.|:||.:                     |.|.||  |.....|.|.
Mouse   111 RRPAHVPLDV----FLEEVSFYGLGA---------------------AALARLREDEGCAVPPER 150

  Fly   149 ELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPD 213
            .|.|:                ....::|.||:.|.||.||:.:.||||..|.:||:.|||:|.||
Mouse   151 PLPRR----------------AFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFCLETLPD 199

  Fly   214 MR--------VPIVRNITVKTANGSNGWFLDKTQTNAHI-----------AFFYIECVCNAWFTF 259
            .|        .|:.         .:.|.||.:...::.:           .||.:|.:|..||:|
Mouse   200 FRDDRDDPGLAPVA---------AATGPFLARLNGSSPMPGAPPRQPFNDPFFVVETLCICWFSF 255

  Fly   260 EILVRFISSPNKWEFIKSSVNIIDYIATLSFYI----DLVLQR-FASHLENADILEFFSIIRIMR 319
            |:|||.::.|:|..|.|:.:|:||::|.|.:::    :|..|| ......:..||....::|:.|
Mouse   256 ELLVRLVACPSKAVFFKNVMNLIDFVAILPYFVALGTELARQRGVGQPAMSLAILRVIRLVRVFR 320

  Fly   320 LFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLW 384
            :|||:|||.||:||.||.|||.:||.||:|||.:|:|:|:|.||:||..:.:.|  |.|||...|
Mouse   321 IFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDTH--FTSIPESFW 383

  Fly   385 WALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYY 435
            ||:|||||||||||||.|..|..||:|||:||||||:||||||||||:.:|
Mouse   384 WAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFY 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	38/102 (37%)
		BTB_2	27..117	CDD:280393	38/94 (40%)
		Ion_trans	244..439	CDD:278921	102/208 (49%)
		Ion_trans_2	355..429	CDD:285168	47/73 (64%)
Kcna7	NP_034726.2	BTB_2	47..137	CDD:280393	40/114 (35%)
		BTB	47..130	CDD:197585	36/86 (42%)
		Ion_trans	228..437	CDD:278921	102/209 (49%)
		Ion_trans_2	352..431	CDD:285168	52/80 (65%)
		Selectivity filter. /evidence=ECO:0000250	391..396		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820