DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shaw and AgaP_AGAP008201

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_317267.4	Gene:	AgaP_AGAP008201 / 1277770	VectorBaseID:	AGAP008201	Length:	512	Species:	Anopheles gambiae

Alignment Length:	499	Identity:	425/499 - (85%)
Similarity:	451/499 - (90%)	Gaps:	10/499 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MNLI-NMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQ 79
            |||: |||||||||||||||||||||||||||||||||||||||.||||:|||||||||||||||
Mosquito     1 MNLMNNMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALGNYDPVLNEYFFDRHPGVFAQ 65

  Fly    80 VLNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEK 144
            |||||||||||||||||||||||||.|||||||||||||||||||||:|||||||||||||||||
Mosquito    66 VLNYYRTGKLHYPTDVCGPLFEEELSFWGLDSNQVEPCCWMTYTQHRNTQETLAVLDRLDLDTEK 130

  Fly   145 PSEEELARKFGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLK 209
            |::||:|:|||||:.|.||.:||||.:||:|||||||||||||||.||::||||||:||:|||||
Mosquito   131 PTDEEVAKKFGFEDAYNKGKVSWWQHLKPQIWSLFDEPYSSNAAKIIGIISVFFICVSIISFCLK 195

  Fly   210 THPDMRVPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEF 274
            ||||||||.:|||||||||.:..|.|||||||||||||||||||||||||||:|||||||:|..|
Mosquito   196 THPDMRVPYIRNITVKTANQNTSWVLDKTQTNAHIAFFYIECVCNAWFTFEIMVRFISSPSKLRF 260

  Fly   275 IKSSVNIIDYIATLSFYIDLVLQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRA 339
            |.||||||||||||||:|||:||||||||||||||||||||||||||||||||||||||||||||
Mosquito   261 ITSSVNIIDYIATLSFFIDLILQRFASHLENADILEFFSIIRIMRLFKLTRHSSGLKILIQTFRA 325

  Fly   340 SAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYI 404
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||.|||||
Mosquito   326 SAKELTLLVFFLVLGIVIFASLVYYAERIQINPHNDFNSIPLGLWWALVTMTTVGYGDMTPKTYI 390

  Fly   405 GMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPG-APGG 468
            |||||||||||||||||||||||||||.||||||||||||||:||||.|||..|.||||| ..||
Mosquito   391 GMFVGALCALAGVLTIALPVPVIVSNFTMYYSHTQARAKLPKRRRRVCPVELSRPPRLPGNCQGG 455

  Fly   469 VSGCGTPGSG--PHSGPMGSGGTGP--RRMN-NK--TKDLVSPK 505
            ...|.| |||  |.|....:|....  |||| |:  |||::.||
Mosquito   456 PGVCNT-GSGKLPSSNAPSTGSMDQAIRRMNANRTITKDVILPK 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	94/97 (97%)
		BTB_2	27..117	CDD:280393	86/89 (97%)
		Ion_trans	244..439	CDD:278921	184/194 (95%)
		Ion_trans_2	355..429	CDD:285168	71/73 (97%)
AgaP_AGAP008201	XP_317267.4	BTB	13..111	CDD:197585	94/97 (97%)
		BTB_2	13..103	CDD:280393	86/89 (97%)
		Ion_trans	230..425	CDD:278921	184/194 (95%)
		Ion_trans_2	341..418	CDD:285168	74/76 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	58	1.000	Domainoid score	I17957
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48788
OrthoDB	1	1.010	-	-		D22145at7147
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
TreeFam	1	0.960	-	-
	9	8.890