DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shaw and AgaP_AGAP007046

DIOPT Version :9

Sequence 1:	NP_001137782.1	Gene:	Shaw / 33599	FlyBaseID:	FBgn0003386	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_308716.2	Gene:	AgaP_AGAP007046 / 1270054	VectorBaseID:	AGAP007046	Length:	550	Species:	Anopheles gambiae

Alignment Length:	562	Identity:	187/562 - (33%)
Similarity:	284/562 - (50%)	Gaps:	74/562 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGK 88
            :.::::||.|.|.||::.|::|.|.|.|.. .|....||....||||||.|.:|..:||||||||
Mosquito    40 DEKLIINVSGRRFETWRTTVEKYPDTLLGS-NERDFFYDEDSKEYFFDRDPDIFRHILNYYRTGK 103

  Fly    89 LHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARK 153
            ||||...|...::|||.|:|:..:.:..||   |..:||.:...|  :|| :| :|.||..
Mosquito   104 LHYPRHECLLSYDEELAFFGIMPDVIGDCC---YEDYRDRKRENA--ERL-MD-DKLSENS---- 157

  Fly   154 FGFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPDMRVPI 218
                    ...:.....::.|:|..|:.|::|.||.....|:.|||.:|:::..::|     ||.
Mosquito   158 --------DNNLQQLTNIRQRMWRAFENPHTSTAALVFYYVTGFFIAVSVMANVVET-----VPC 209

  Fly   219 -VRNITVKTANGSNGWFLDKTQTNAHIAFFYIECVCNAWFTFEILVRFISSPNKWEFIKSSVNII 282
             ||.....|.:....:         .|.||.::..|...||.|.|:|..::|.:.:|::|.::||
Mosquito   210 GVRPGRAGTLSCGERY---------KIVFFCLDTACVMIFTAEYLLRLFAAPCRCKFVRSVMSII 265

  Fly   283 DYIATLSFYIDLVLQRFASHLENADILEFF---SIIRIMRLFKLTRHSSGLKILIQTFRASAKEL 344
            |.:|.|.:||.|.:      .:|.|:...|   .:.|:.|:||.:|||.||:||..|.::.|.||
Mosquito   266 DVVAILPYYIGLGI------TDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL 324

  Fly   345 TLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVG 409
            ..|||.|.:.|:|||::::|||:....  .:|.|||...|:.:|||||:|||||.|:|..|..||
Mosquito   325 GFLVFSLAMAIIIFATVMFYAEKNVDG--TNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387

  Fly   410 ALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRRVLPVEQPRQPRLPGAPGGVSGCGT 474
            .:|:|:|||.||||||||||||:..| |...||...|.:|:.      |..|:..|..|.|....
Mosquito   388 GVCSLSGVLVIALPVPVIVSNFSRIY-HQNQRADKRKAQRKA------RLARIRIAKAGASAAFA 445

  Fly   475 PGSGPHSGPMGSGGTGPRRMNNKTKDLVSPKSVAQLFAGPLGASIVAMSPRTMLDLNPALAMGKP 539
            .........:.:..:|     .:..|..:.:.:.:|....|...:...:.|..::|.  ......
Mosquito   446 SKKKAAESRLAAQESG-----IELDDNYNDEDIFELQHHHLLRCLEKTTDREFVELE--TQYNGQ 503

  Fly   540 TFQPRIPTPLAATPPPPVSSAGGMTASGIGTTSATGATSAPQ 581
            |.:|..|:|:|:    |..||          .:|||||...|
Mosquito   504 TKRPGSPSPMAS----PSHSA----------NTATGATGLLQ 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shaw	NP_001137782.1	BTB	27..125	CDD:197585	43/97 (44%)
		BTB_2	27..117	CDD:280393	40/89 (45%)
		Ion_trans	244..439	CDD:278921	88/197 (45%)
		Ion_trans_2	355..429	CDD:285168	40/73 (55%)
AgaP_AGAP007046	XP_308716.2	BTB_POZ_Shal-like	6..144	CDD:349727	45/107 (42%)
		Ion_trans	184..415	CDD:395416	99/253 (39%)
		DUF3399	459..543	CDD:403174	20/94 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
TreeFam	0	0.000	Not matched by this tool.
	3	2.810